Long-range interlayer alignment of intralayer domains in stacked lipid bilayers

Lobat Tayebi, Yicong Ma, Daryoosh Vashaee, Gang Chen, Sunil K. Sinha, Atul N. Parikh

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Liquid-crystalline phases of stacked lipid bilayers represent a pervasive motif in biomolecular assemblies. Here we report that, in addition to the usual smectic order, multicomponent multilayer membranes can exhibit columnar order arising from the coupling of two-dimensional intralayer phase separation and interlayer smectic ordering. This coupling propagates across hundreds of membrane lamellae, producing long-range alignment of phase-separated domains. Quantitative analysis of real-time dynamical experiments reveals that there is an interplay between intralayer domain growth and interlayer coupling, suggesting the existence of cooperative multilayer epitaxy. We postulate that such long-range epitaxy is solvent-assisted, and that it originates from the surface tension associated with differences in the network of hydrogen-bonded water molecules at the hydrated interfaces between the domains and the surrounding phase. Our findings might inspire the development of self-assembly-based strategies for the long-range alignment of functional lipid domains.

Original languageEnglish (US)
Pages (from-to)1074-1080
Number of pages7
JournalNature Materials
Volume11
Issue number12
DOIs
StatePublished - Dec 2012

Fingerprint

Lipid bilayers
Epitaxial growth
lipids
interlayers
Multilayers
alignment
Membranes
Phase separation
epitaxy
Self assembly
Lipids
Surface tension
Hydrogen
Crystalline materials
membranes
Molecules
Water
Liquids
lamella
axioms

ASJC Scopus subject areas

  • Mechanical Engineering
  • Mechanics of Materials
  • Condensed Matter Physics
  • Materials Science(all)
  • Chemistry(all)

Cite this

Tayebi, L., Ma, Y., Vashaee, D., Chen, G., Sinha, S. K., & Parikh, A. N. (2012). Long-range interlayer alignment of intralayer domains in stacked lipid bilayers. Nature Materials, 11(12), 1074-1080. https://doi.org/10.1038/nmat3451

Long-range interlayer alignment of intralayer domains in stacked lipid bilayers. / Tayebi, Lobat; Ma, Yicong; Vashaee, Daryoosh; Chen, Gang; Sinha, Sunil K.; Parikh, Atul N.

In: Nature Materials, Vol. 11, No. 12, 12.2012, p. 1074-1080.

Research output: Contribution to journalArticle

Tayebi, L, Ma, Y, Vashaee, D, Chen, G, Sinha, SK & Parikh, AN 2012, 'Long-range interlayer alignment of intralayer domains in stacked lipid bilayers', Nature Materials, vol. 11, no. 12, pp. 1074-1080. https://doi.org/10.1038/nmat3451
Tayebi L, Ma Y, Vashaee D, Chen G, Sinha SK, Parikh AN. Long-range interlayer alignment of intralayer domains in stacked lipid bilayers. Nature Materials. 2012 Dec;11(12):1074-1080. https://doi.org/10.1038/nmat3451
Tayebi, Lobat ; Ma, Yicong ; Vashaee, Daryoosh ; Chen, Gang ; Sinha, Sunil K. ; Parikh, Atul N. / Long-range interlayer alignment of intralayer domains in stacked lipid bilayers. In: Nature Materials. 2012 ; Vol. 11, No. 12. pp. 1074-1080.
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