Abstract
Liquid-crystalline phases of stacked lipid bilayers represent a pervasive motif in biomolecular assemblies. Here we report that, in addition to the usual smectic order, multicomponent multilayer membranes can exhibit columnar order arising from the coupling of two-dimensional intralayer phase separation and interlayer smectic ordering. This coupling propagates across hundreds of membrane lamellae, producing long-range alignment of phase-separated domains. Quantitative analysis of real-time dynamical experiments reveals that there is an interplay between intralayer domain growth and interlayer coupling, suggesting the existence of cooperative multilayer epitaxy. We postulate that such long-range epitaxy is solvent-assisted, and that it originates from the surface tension associated with differences in the network of hydrogen-bonded water molecules at the hydrated interfaces between the domains and the surrounding phase. Our findings might inspire the development of self-assembly-based strategies for the long-range alignment of functional lipid domains.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1074-1080 |
| Number of pages | 7 |
| Journal | Nature Materials |
| Volume | 11 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2012 |
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ASJC Scopus subject areas
- Mechanical Engineering
- Mechanics of Materials
- Condensed Matter Physics
- Materials Science(all)
- Chemistry(all)
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Long-range interlayer alignment of intralayer domains in stacked lipid bilayers. / Tayebi, Lobat; Ma, Yicong; Vashaee, Daryoosh; Chen, Gang; Sinha, Sunil K.; Parikh, Atul N.
In: Nature Materials, Vol. 11, No. 12, 12.2012, p. 1074-1080.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-range interlayer alignment of intralayer domains in stacked lipid bilayers
AU - Tayebi, Lobat
AU - Ma, Yicong
AU - Vashaee, Daryoosh
AU - Chen, Gang
AU - Sinha, Sunil K.
AU - Parikh, Atul N.
PY - 2012/12
Y1 - 2012/12
N2 - Liquid-crystalline phases of stacked lipid bilayers represent a pervasive motif in biomolecular assemblies. Here we report that, in addition to the usual smectic order, multicomponent multilayer membranes can exhibit columnar order arising from the coupling of two-dimensional intralayer phase separation and interlayer smectic ordering. This coupling propagates across hundreds of membrane lamellae, producing long-range alignment of phase-separated domains. Quantitative analysis of real-time dynamical experiments reveals that there is an interplay between intralayer domain growth and interlayer coupling, suggesting the existence of cooperative multilayer epitaxy. We postulate that such long-range epitaxy is solvent-assisted, and that it originates from the surface tension associated with differences in the network of hydrogen-bonded water molecules at the hydrated interfaces between the domains and the surrounding phase. Our findings might inspire the development of self-assembly-based strategies for the long-range alignment of functional lipid domains.
AB - Liquid-crystalline phases of stacked lipid bilayers represent a pervasive motif in biomolecular assemblies. Here we report that, in addition to the usual smectic order, multicomponent multilayer membranes can exhibit columnar order arising from the coupling of two-dimensional intralayer phase separation and interlayer smectic ordering. This coupling propagates across hundreds of membrane lamellae, producing long-range alignment of phase-separated domains. Quantitative analysis of real-time dynamical experiments reveals that there is an interplay between intralayer domain growth and interlayer coupling, suggesting the existence of cooperative multilayer epitaxy. We postulate that such long-range epitaxy is solvent-assisted, and that it originates from the surface tension associated with differences in the network of hydrogen-bonded water molecules at the hydrated interfaces between the domains and the surrounding phase. Our findings might inspire the development of self-assembly-based strategies for the long-range alignment of functional lipid domains.
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UR - http://www.scopus.com/inward/citedby.url?scp=84870053011&partnerID=8YFLogxK
U2 - 10.1038/nmat3451
DO - 10.1038/nmat3451
M3 - Article
C2 - 23085566
AN - SCOPUS:84870053011
VL - 11
SP - 1074
EP - 1080
JO - Nature Materials
JF - Nature Materials
SN - 1476-1122
IS - 12
ER -