Long-lasting facilitation of a synaptic potential following tetanization in the in vitro hippocampal slice

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Abstract

Field potentials evoked by stimulation of afferent fibers in stratum radiatum were recorded in the CA1 region of the hippocampal slice maintained in vitro. Stimulation rates of 3-50/sec produced a large increase in amplitude of the population spike in CA1. This increase was maintained for several hours after the tetanization. The facilitation phenomenon appeared to be specific to the synapse of stratum radiatum afferents onto CA1 pyramidal cells since: (1) stimulation outside the radiatum layer did not produce the effect, (2) antidromic field potentials recorded in CA3 were unchanged, (3) EPSP threshold in CA1 was unchanged, and (4) alveus tetanization did not produce a facilitatory effect.

Original languageEnglish (US)
Pages (from-to)107-119
Number of pages13
JournalBrain Research
Volume89
Issue number1
DOIs
StatePublished - May 16 1975
Externally publishedYes

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Hippocampal CA1 Region
Synaptic Potentials
Pyramidal Cells
Excitatory Postsynaptic Potentials
Evoked Potentials
Synapses
Population
In Vitro Techniques

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Long-lasting facilitation of a synaptic potential following tetanization in the in vitro hippocampal slice. / Schwartzkroin, Philip A; Wester, Knut.

In: Brain Research, Vol. 89, No. 1, 16.05.1975, p. 107-119.

Research output: Contribution to journalArticle

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