Abstract
A cohort of 22 rhesus macaques of Indian origin infected as neonates, juveniles, or adults by Rev-independent strains of SIV was monitored over several years. After the initial acute phase, virus replication was controlled and plasma virus loads were persistently below the threshold of the assay. The animals were monitored for up to 7.6 years after infection for viral loads, cellular and humoral immune responses, hematological changes, and overall health and no signs of immune dysfunction or AIDS were observed. This study represents several years of additional observation compared to the previously published results, and indicates that the Rev-independent SIV clones tested do not cause AIDS-like progressive disease within 7.6 years from infection. All the animals showed persistent humoral and cellular SIV-specific immune responses, consistent with chronic infection. Different Rev-independent SIV strains showed similar properties and lack of pathogenicity. Multicolor flow cytometric analysis demonstrated preservation of the Central Memory subset of T cells in the attenuated SIV-infected animals. This study demonstrates a potent, long-lasting control of the Rev-independent attenuated SIV in macaques independent of the age at virus exposure.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 516-528 |
| Number of pages | 13 |
| Journal | AIDS Research and Human Retroviruses |
| Volume | 22 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2006 |
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ASJC Scopus subject areas
- Immunology
- Virology
- Infectious Diseases
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Long lasting control and lack of pathogenicity of the attenuated Rev-independent SIV in rhesus macaques. / Von Gegerfelt, Agneta S.; Alicea, Candido; Valentin, Antonio; Morrow, Matthew; Van Rompay, Koen K.A.; Ayash-Rashkovsky, Mila; Markham, Phillip; Else, James G.; Marthas, Marta; Pavlakis, George N.; Ruprecht, Ruth M.; Felber, Barbara K.
In: AIDS Research and Human Retroviruses, Vol. 22, No. 6, 01.06.2006, p. 516-528.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long lasting control and lack of pathogenicity of the attenuated Rev-independent SIV in rhesus macaques
AU - Von Gegerfelt, Agneta S.
AU - Alicea, Candido
AU - Valentin, Antonio
AU - Morrow, Matthew
AU - Van Rompay, Koen K.A.
AU - Ayash-Rashkovsky, Mila
AU - Markham, Phillip
AU - Else, James G.
AU - Marthas, Marta
AU - Pavlakis, George N.
AU - Ruprecht, Ruth M.
AU - Felber, Barbara K.
PY - 2006/6/1
Y1 - 2006/6/1
N2 - A cohort of 22 rhesus macaques of Indian origin infected as neonates, juveniles, or adults by Rev-independent strains of SIV was monitored over several years. After the initial acute phase, virus replication was controlled and plasma virus loads were persistently below the threshold of the assay. The animals were monitored for up to 7.6 years after infection for viral loads, cellular and humoral immune responses, hematological changes, and overall health and no signs of immune dysfunction or AIDS were observed. This study represents several years of additional observation compared to the previously published results, and indicates that the Rev-independent SIV clones tested do not cause AIDS-like progressive disease within 7.6 years from infection. All the animals showed persistent humoral and cellular SIV-specific immune responses, consistent with chronic infection. Different Rev-independent SIV strains showed similar properties and lack of pathogenicity. Multicolor flow cytometric analysis demonstrated preservation of the Central Memory subset of T cells in the attenuated SIV-infected animals. This study demonstrates a potent, long-lasting control of the Rev-independent attenuated SIV in macaques independent of the age at virus exposure.
AB - A cohort of 22 rhesus macaques of Indian origin infected as neonates, juveniles, or adults by Rev-independent strains of SIV was monitored over several years. After the initial acute phase, virus replication was controlled and plasma virus loads were persistently below the threshold of the assay. The animals were monitored for up to 7.6 years after infection for viral loads, cellular and humoral immune responses, hematological changes, and overall health and no signs of immune dysfunction or AIDS were observed. This study represents several years of additional observation compared to the previously published results, and indicates that the Rev-independent SIV clones tested do not cause AIDS-like progressive disease within 7.6 years from infection. All the animals showed persistent humoral and cellular SIV-specific immune responses, consistent with chronic infection. Different Rev-independent SIV strains showed similar properties and lack of pathogenicity. Multicolor flow cytometric analysis demonstrated preservation of the Central Memory subset of T cells in the attenuated SIV-infected animals. This study demonstrates a potent, long-lasting control of the Rev-independent attenuated SIV in macaques independent of the age at virus exposure.
UR - http://www.scopus.com/inward/record.url?scp=33745684330&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745684330&partnerID=8YFLogxK
U2 - 10.1089/aid.2006.22.516
DO - 10.1089/aid.2006.22.516
M3 - Article
C2 - 16796527
AN - SCOPUS:33745684330
VL - 22
SP - 516
EP - 528
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
SN - 0889-2229
IS - 6
ER -