Long lasting control and lack of pathogenicity of the attenuated Rev-independent SIV in rhesus macaques

Agneta S. Von Gegerfelt, Candido Alicea, Antonio Valentin, Matthew Morrow, Koen K.A. Van Rompay, Mila Ayash-Rashkovsky, Phillip Markham, James G. Else, Marta Marthas, George N. Pavlakis, Ruth M. Ruprecht, Barbara K. Felber

Research output: Contribution to journalArticle

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Abstract

A cohort of 22 rhesus macaques of Indian origin infected as neonates, juveniles, or adults by Rev-independent strains of SIV was monitored over several years. After the initial acute phase, virus replication was controlled and plasma virus loads were persistently below the threshold of the assay. The animals were monitored for up to 7.6 years after infection for viral loads, cellular and humoral immune responses, hematological changes, and overall health and no signs of immune dysfunction or AIDS were observed. This study represents several years of additional observation compared to the previously published results, and indicates that the Rev-independent SIV clones tested do not cause AIDS-like progressive disease within 7.6 years from infection. All the animals showed persistent humoral and cellular SIV-specific immune responses, consistent with chronic infection. Different Rev-independent SIV strains showed similar properties and lack of pathogenicity. Multicolor flow cytometric analysis demonstrated preservation of the Central Memory subset of T cells in the attenuated SIV-infected animals. This study demonstrates a potent, long-lasting control of the Rev-independent attenuated SIV in macaques independent of the age at virus exposure.

Original languageEnglish (US)
Pages (from-to)516-528
Number of pages13
JournalAIDS Research and Human Retroviruses
Volume22
Issue number6
DOIs
StatePublished - Jun 1 2006

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Macaca mulatta
Virulence
Acquired Immunodeficiency Syndrome
Infection
Viruses
Macaca
T-Lymphocyte Subsets
Humoral Immunity
Virus Replication
Viral Load
Cellular Immunity
Clone Cells
Observation
Health

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

Cite this

Von Gegerfelt, A. S., Alicea, C., Valentin, A., Morrow, M., Van Rompay, K. K. A., Ayash-Rashkovsky, M., ... Felber, B. K. (2006). Long lasting control and lack of pathogenicity of the attenuated Rev-independent SIV in rhesus macaques. AIDS Research and Human Retroviruses, 22(6), 516-528. https://doi.org/10.1089/aid.2006.22.516

Long lasting control and lack of pathogenicity of the attenuated Rev-independent SIV in rhesus macaques. / Von Gegerfelt, Agneta S.; Alicea, Candido; Valentin, Antonio; Morrow, Matthew; Van Rompay, Koen K.A.; Ayash-Rashkovsky, Mila; Markham, Phillip; Else, James G.; Marthas, Marta; Pavlakis, George N.; Ruprecht, Ruth M.; Felber, Barbara K.

In: AIDS Research and Human Retroviruses, Vol. 22, No. 6, 01.06.2006, p. 516-528.

Research output: Contribution to journalArticle

Von Gegerfelt, AS, Alicea, C, Valentin, A, Morrow, M, Van Rompay, KKA, Ayash-Rashkovsky, M, Markham, P, Else, JG, Marthas, M, Pavlakis, GN, Ruprecht, RM & Felber, BK 2006, 'Long lasting control and lack of pathogenicity of the attenuated Rev-independent SIV in rhesus macaques', AIDS Research and Human Retroviruses, vol. 22, no. 6, pp. 516-528. https://doi.org/10.1089/aid.2006.22.516
Von Gegerfelt AS, Alicea C, Valentin A, Morrow M, Van Rompay KKA, Ayash-Rashkovsky M et al. Long lasting control and lack of pathogenicity of the attenuated Rev-independent SIV in rhesus macaques. AIDS Research and Human Retroviruses. 2006 Jun 1;22(6):516-528. https://doi.org/10.1089/aid.2006.22.516
Von Gegerfelt, Agneta S. ; Alicea, Candido ; Valentin, Antonio ; Morrow, Matthew ; Van Rompay, Koen K.A. ; Ayash-Rashkovsky, Mila ; Markham, Phillip ; Else, James G. ; Marthas, Marta ; Pavlakis, George N. ; Ruprecht, Ruth M. ; Felber, Barbara K. / Long lasting control and lack of pathogenicity of the attenuated Rev-independent SIV in rhesus macaques. In: AIDS Research and Human Retroviruses. 2006 ; Vol. 22, No. 6. pp. 516-528.
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