Long HIV-1 incubation periods and dynamics of transmission within a family

Harold Burger, K. Flaherty, J. Gulla, Barbara Weiser, A. Kaell, H. Burger, B. Weiser, A. L. Belman, R. Grimson, R. A. Gibbs, P. N. Nguyen

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


The incubation period of human immuno-deficiency virus type 1 (HIV-1) infection was studied in a family of five in which vertical and heterosexual transmission occurred from one index case. This investigation documented incubation periods of longer than 12 years in a mother and her daughter; although neither has symptoms, both are definitely infected and have very low CD4+-lymphocyte counts. The study confirmed the predictions of incubation periods longer than 10 years in a small proportion of infected individuals. It provides evidence that vertically HIV-1-infected teenagers can be expected to appear in the population.

Original languageEnglish (US)
Pages (from-to)134-136
Number of pages3
JournalThe Lancet
Issue number8708
StatePublished - Jul 21 1990
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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