Long-distance charge transport in duplex DNA: The phonon-assisted polaron-like hopping mechanism

Paul Henderson, Denise Jones, Gregory Hampikian, Yongzhi Kan, Gary B. Schuster

Research output: Contribution to journalArticle

507 Citations (Scopus)

Abstract

An anthraquinone-linked duplex DNA oligomer containing 60 base pairs was synthesized by PCR. The strand complementary to the quinone-containing strand has four isolated GG steps, which serve as traps for a migrating radical cation. Irradiation of the quinone leads to electron transfer from the DNA to the quinone forming the anthraquinone radical anion and a base radical cation. The radical cation migrates through the DNA, causing reaction at GG steps revealed as strand breaks. The efficiency of strand cleavage falls off exponentially with distance from the quinone (slope = -0.02 Å-1). This finding necessitates reinterpretation of mechanisms proposed for radical cation migration in DNA. We propose that radical cations form self-trapped polarons that migrate by thermally activated hopping.

Original languageEnglish (US)
Pages (from-to)8353-8358
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume96
Issue number15
DOIs
StatePublished - Jul 20 1999
Externally publishedYes

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Phonons
Gene Conversion
Cations
DNA
Anthraquinones
Base Pairing
Anions
Electrons
Polymerase Chain Reaction
benzoquinone

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Long-distance charge transport in duplex DNA : The phonon-assisted polaron-like hopping mechanism. / Henderson, Paul; Jones, Denise; Hampikian, Gregory; Kan, Yongzhi; Schuster, Gary B.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, No. 15, 20.07.1999, p. 8353-8358.

Research output: Contribution to journalArticle

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