Localized thermo-cisplatin therapy: A pilot study in spontaneous canine and feline tumours

Alain P Theon, B. R. Madewell, A. S. Moore, C. Stephens, D. N. Krag

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Local hyperthermia combined with intralesional cisplatin chemotherapy is a logical and potentially effective therapeutic approach for localized cancers. A trial using out bred animals with spontaneously occurring tumours was initiated to evaluate the toxicity and efficacy of this approach. Treatment consisted of injection of a colloidal suspension of cisplatin into the tumour prior to hyperthermia once a week for 4 weeks. Immediately after intratumoral injection of a mixture of cisplatin and collagen, thermotherapy was given. The goal temperature was 42 ± 1° for 30 min. Ten animals (nine dogs and one cat) with soft tissue neoplasms were treated with one to four hyperthermia and cisplatin sessions for a total of 30 treatment sessions. Complete responses occurred in 4/10 cases (one carcinoma, two sarcomas, one melanoma). One dog with haem-angiopericytoma had partial response. The lack of systemic toxicity and the minimal local normal tissue reactions indicate that the treatments were well tolerated. These data provide preliminary evidence that a combination of local hyperthermia and intratumoral cisplatin chemotherapy is a safe and effective method for the treatment of selected localized neoplasms.

Original languageEnglish (US)
Pages (from-to)881-892
Number of pages12
JournalInternational Journal of Hyperthermia
Volume7
Issue number6
DOIs
StatePublished - 1991

Keywords

  • Animal spontaneous tumours
  • Cisplatin
  • Collagen
  • Localized hyperthermia

ASJC Scopus subject areas

  • Cancer Research
  • Physiology
  • Radiological and Ultrasound Technology
  • Physiology (medical)

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