Localized measures of callosal atrophy are associated with late-life hypertension: AGES-Reykjavik Study

Peter Harris, Dan A. Alcantara, Nina Amenta, Oscar L. Lopez, Gudný Eiríksdóttir, Sigurdur Sigurdsson, Villmundur Gudnason, Sarah Madsen, Paul M. Thompson, Lenore J. Launer, Owen T. Carmichael

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Hypertension is highly prevalent in elderly individuals and may be associated with cognitive decline, but the mechanisms by which hypertension may impact brain structure, and thereby modulate the time course of late-life cognitive performance, are not well understood. Therefore we used Localized Components Analysis, a novel computational method, to measure spatially-localized patterns of corpus callosum (CC) atrophy in 28 right-handed female subjects aged 75-79 years in the Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-Reykjavik), a large-scale epidemiological study of aging. Localized callosal atrophy in the posterior midbody and splenium was significantly associated with systolic blood pressure in linear statistical models that controlled for age, while associations between blood pressure and anterior CC atrophy measures were not statistically significant. Additionally, overall measures of global CC atrophy were not significantly associated with blood pressure. The posterior CC may be differentially vulnerable to hypertension-associated atrophy, possibly due to its relatively tenuous vascularization.

Original languageEnglish (US)
Pages (from-to)489-496
Number of pages8
Issue number3
StatePublished - Nov 15 2008

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology


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