Localized functional age-related changes in the central retina assessed by multifocal ERG

Radouil Tzekov, Christina Gerth, John S Werner

Research output: Contribution to journalArticlepeer-review


Introduction: Previous studies have shown significant age-related change in the first-order kernel response of the multifocal ERG (mfERG). However, they all involved use of ring averages across the retinal field. Purpose: To estimate the age-related changes in the localized response and retinal topography using point-to-point comparison. To determine the localized variability in the mfERG scalar product across age and the topography of the age-related change. Methods: MfERG recordings of 71 normal phakic subjects (ages 9-80) were analyzed with VERIS TM 4.8. The stimulus parameters were: 103 hexagons, 75 Hz frame rate, peak luminance 200 cd/m2, m= 2 14. Scalar products (for each hexagon based on ring average templates) were obtained and analyzed for age-related changes. Statistical measures (coefficient of variation (CV) and parameters of a linear regression model) were applied. Point-by-point comparison for hemifields was performed. Results: Each localized response showed a significant aging effect. The average decline of the response for all hexagons was ∼15%/decade varying from 3.3% (peripherally) to 7.5% (perifoveally). The average CV for all subjects at all locations was 29.4% (± 4.1%). The CV distribution was relatively homogenous across the retina except for a small region around the optic disc (4 hexagons), which was excluded from further analysis. Topographical maps of the parameters of the linear regression model showed a distribution that was different from the topography of the ring averages. The rate of change was significantly higher for the superior then for the inferior retina, but no naso-temporal asymmetry with age was found. Conclusions: Our data for CV are consistent with the data previously reported for samples with a more restricted age range. Information about change of individual hexagons with age should make the mfERG more useful in quantitatively monitoring progression of retinal disease.

Original languageEnglish (US)
JournalJournal of Vision
Issue number10
StatePublished - 2002


  • Glaucoma &fields

ASJC Scopus subject areas

  • Ophthalmology


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