Pulmonary alveolar macrophages manifest a Mg++ dependent Na+-K+ stimulated ATPase activity. A survey of ATP hydrolyzing activity in various subcellular fractions reveals that the maximal activity is found in a fraction containing predominantly the macrophage plasma membrane. This Na+K+, Mg++ ATPase is sensitive to ouabain and p-chloromercuribenzoate but insensitive to oligomycin. This enzyme system may be related to energy-dependent membrane-linked processes of alveolar macrophages.
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