Localization of Na+K+, Mg++ adenos inetriphosphatase activity in pulmonary alveolar macrophage subcellular fractions

Mohammad G. Mustafa; Carroll E Cross; Jeanne A. Hardie

doi:10.1016/0024-3205(70)90080-9

Localization of Na⁺K⁺, Mg⁺⁺ adenos inetriphosphatase activity in pulmonary alveolar macrophage subcellular fractions

Mohammad G. Mustafa, Carroll E Cross, Jeanne A. Hardie

Pulmonary, Critical Care, and Sleep Medicine

Research output: Contribution to journal › Article

7 Citations (Scopus)

Abstract

Pulmonary alveolar macrophages manifest a Mg⁺⁺ dependent Na⁺-K⁺ stimulated ATPase activity. A survey of ATP hydrolyzing activity in various subcellular fractions reveals that the maximal activity is found in a fraction containing predominantly the macrophage plasma membrane. This Na⁺K⁺, Mg⁺⁺ ATPase is sensitive to ouabain and p-chloromercuribenzoate but insensitive to oligomycin. This enzyme system may be related to energy-dependent membrane-linked processes of alveolar macrophages.

Original language	English (US)
Pages (from-to)	947-954
Number of pages	8
Journal	Life Sciences
Volume	9
Issue number	16 PART 1
DOIs	https://doi.org/10.1016/0024-3205(70)90080-9
State	Published - Aug 15 1970

Fingerprint

Subcellular Fractions

Alveolar Macrophages

Chloromercuribenzoates

Oligomycins

Macrophages

Ouabain

Cell membranes

Adenosine Triphosphatases

Adenosine Triphosphate

Membranes

Enzymes

Cell Membrane

magnesium sodium potassium ATPase

ASJC Scopus subject areas

Pharmacology
Medicine(all)

Cite this

Mustafa, M. G., Cross, C. E., & Hardie, J. A. (1970). Localization of Na⁺K⁺, Mg⁺⁺ adenos inetriphosphatase activity in pulmonary alveolar macrophage subcellular fractions. Life Sciences, 9(16 PART 1), 947-954. https://doi.org/10.1016/0024-3205(70)90080-9

Localization of Na⁺K⁺, Mg⁺⁺ adenos inetriphosphatase activity in pulmonary alveolar macrophage subcellular fractions. / Mustafa, Mohammad G.; Cross, Carroll E; Hardie, Jeanne A.

In: Life Sciences, Vol. 9, No. 16 PART 1, 15.08.1970, p. 947-954.

Research output: Contribution to journal › Article

Mustafa, MG, Cross, CE & Hardie, JA 1970, 'Localization of Na⁺K⁺, Mg⁺⁺ adenos inetriphosphatase activity in pulmonary alveolar macrophage subcellular fractions', Life Sciences, vol. 9, no. 16 PART 1, pp. 947-954. https://doi.org/10.1016/0024-3205(70)90080-9

Mustafa MG, Cross CE, Hardie JA. Localization of Na⁺K⁺, Mg⁺⁺ adenos inetriphosphatase activity in pulmonary alveolar macrophage subcellular fractions. Life Sciences. 1970 Aug 15;9(16 PART 1):947-954. https://doi.org/10.1016/0024-3205(70)90080-9

Mustafa, Mohammad G. ; Cross, Carroll E ; Hardie, Jeanne A. / Localization of Na⁺K⁺, Mg⁺⁺ adenos inetriphosphatase activity in pulmonary alveolar macrophage subcellular fractions. In: Life Sciences. 1970 ; Vol. 9, No. 16 PART 1. pp. 947-954.

@article{7bef697d8e2a4a929e99b6a4603ec2c7,

title = "Localization of Na+K+, Mg++ adenos inetriphosphatase activity in pulmonary alveolar macrophage subcellular fractions",

abstract = "Pulmonary alveolar macrophages manifest a Mg++ dependent Na+-K+ stimulated ATPase activity. A survey of ATP hydrolyzing activity in various subcellular fractions reveals that the maximal activity is found in a fraction containing predominantly the macrophage plasma membrane. This Na+K+, Mg++ ATPase is sensitive to ouabain and p-chloromercuribenzoate but insensitive to oligomycin. This enzyme system may be related to energy-dependent membrane-linked processes of alveolar macrophages.",

author = "Mustafa, {Mohammad G.} and Cross, {Carroll E} and Hardie, {Jeanne A.}",

year = "1970",

month = "8",

day = "15",

doi = "10.1016/0024-3205(70)90080-9",

language = "English (US)",

volume = "9",

pages = "947--954",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "16 PART 1",

}

TY - JOUR

T1 - Localization of Na+K+, Mg++ adenos inetriphosphatase activity in pulmonary alveolar macrophage subcellular fractions

AU - Mustafa, Mohammad G.

AU - Cross, Carroll E

AU - Hardie, Jeanne A.

PY - 1970/8/15

Y1 - 1970/8/15

N2 - Pulmonary alveolar macrophages manifest a Mg++ dependent Na+-K+ stimulated ATPase activity. A survey of ATP hydrolyzing activity in various subcellular fractions reveals that the maximal activity is found in a fraction containing predominantly the macrophage plasma membrane. This Na+K+, Mg++ ATPase is sensitive to ouabain and p-chloromercuribenzoate but insensitive to oligomycin. This enzyme system may be related to energy-dependent membrane-linked processes of alveolar macrophages.

AB - Pulmonary alveolar macrophages manifest a Mg++ dependent Na+-K+ stimulated ATPase activity. A survey of ATP hydrolyzing activity in various subcellular fractions reveals that the maximal activity is found in a fraction containing predominantly the macrophage plasma membrane. This Na+K+, Mg++ ATPase is sensitive to ouabain and p-chloromercuribenzoate but insensitive to oligomycin. This enzyme system may be related to energy-dependent membrane-linked processes of alveolar macrophages.

UR - http://www.scopus.com/inward/record.url?scp=0014948799&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0014948799&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(70)90080-9

DO - 10.1016/0024-3205(70)90080-9

M3 - Article

C2 - 4249840

AN - SCOPUS:0014948799

VL - 9

SP - 947

EP - 954

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 16 PART 1

ER -

Access to Document

10.1016/0024-3205(70)90080-9