Localization of Na+K+, Mg++ adenos inetriphosphatase activity in pulmonary alveolar macrophage subcellular fractions

Mohammad G. Mustafa, Carroll E Cross, Jeanne A. Hardie

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Pulmonary alveolar macrophages manifest a Mg++ dependent Na+-K+ stimulated ATPase activity. A survey of ATP hydrolyzing activity in various subcellular fractions reveals that the maximal activity is found in a fraction containing predominantly the macrophage plasma membrane. This Na+K+, Mg++ ATPase is sensitive to ouabain and p-chloromercuribenzoate but insensitive to oligomycin. This enzyme system may be related to energy-dependent membrane-linked processes of alveolar macrophages.

Original languageEnglish (US)
Pages (from-to)947-954
Number of pages8
JournalLife Sciences
Issue number16 PART 1
StatePublished - Aug 15 1970


ASJC Scopus subject areas

  • Pharmacology
  • Medicine(all)

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