Localization of Na+K+, Mg++ adenos inetriphosphatase activity in pulmonary alveolar macrophage subcellular fractions

Mohammad G. Mustafa, Carroll E Cross, Jeanne A. Hardie

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Pulmonary alveolar macrophages manifest a Mg++ dependent Na+-K+ stimulated ATPase activity. A survey of ATP hydrolyzing activity in various subcellular fractions reveals that the maximal activity is found in a fraction containing predominantly the macrophage plasma membrane. This Na+K+, Mg++ ATPase is sensitive to ouabain and p-chloromercuribenzoate but insensitive to oligomycin. This enzyme system may be related to energy-dependent membrane-linked processes of alveolar macrophages.

Original languageEnglish (US)
Pages (from-to)947-954
Number of pages8
JournalLife Sciences
Volume9
Issue number16 PART 1
DOIs
StatePublished - Aug 15 1970

Fingerprint

Subcellular Fractions
Alveolar Macrophages
Chloromercuribenzoates
Oligomycins
Macrophages
Ouabain
Cell membranes
Adenosine Triphosphatases
Adenosine Triphosphate
Membranes
Enzymes
Cell Membrane
magnesium sodium potassium ATPase

ASJC Scopus subject areas

  • Pharmacology
  • Medicine(all)

Cite this

Localization of Na+K+, Mg++ adenos inetriphosphatase activity in pulmonary alveolar macrophage subcellular fractions. / Mustafa, Mohammad G.; Cross, Carroll E; Hardie, Jeanne A.

In: Life Sciences, Vol. 9, No. 16 PART 1, 15.08.1970, p. 947-954.

Research output: Contribution to journalArticle

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