Localization of Murine Macrophage Inducible Nitric Oxide Synthase to Mouse Chromosome 11

Margarete Mehrabian; Yu Rong Xia; Ping Zi Wen; Craig H Warden; Harvey R. Herschman; Aldons J. Lusis

doi:10.1006/geno.1994.1441

Localization of Murine Macrophage Inducible Nitric Oxide Synthase to Mouse Chromosome 11

Margarete Mehrabian, Yu Rong Xia, Ping Zi Wen, Craig H Warden, Harvey R. Herschman, Aldons J. Lusis

General Pediatrics

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

There are at least three distinct nitric oxide (NO) synthase genes. Brain and endothelial NO synthases are constitutively synthesized, while NO synthase is inducible by cytokines in macropbages. We have utilized a backcross of (C57BL/6J × Mus spretus) × C57BL/6J to map the inducible NO synthase (Nos2). We report the chromosomal mapping of Nos2 to mouse chromosome 11, 3.3cM proximal to Scya2.

Original language	English (US)
Pages (from-to)	646-647
Number of pages	2
Journal	Genomics
Volume	22
Issue number	3
DOIs	https://doi.org/10.1006/geno.1994.1441
State	Published - Aug 1994

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Genetics

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abstract = "There are at least three distinct nitric oxide (NO) synthase genes. Brain and endothelial NO synthases are constitutively synthesized, while NO synthase is inducible by cytokines in macropbages. We have utilized a backcross of (C57BL/6J × Mus spretus) × C57BL/6J to map the inducible NO synthase (Nos2). We report the chromosomal mapping of Nos2 to mouse chromosome 11, 3.3cM proximal to Scya2.",

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AU - Mehrabian, Margarete

AU - Xia, Yu Rong

AU - Wen, Ping Zi

AU - Warden, Craig H

AU - Herschman, Harvey R.

AU - Lusis, Aldons J.

PY - 1994/8

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AB - There are at least three distinct nitric oxide (NO) synthase genes. Brain and endothelial NO synthases are constitutively synthesized, while NO synthase is inducible by cytokines in macropbages. We have utilized a backcross of (C57BL/6J × Mus spretus) × C57BL/6J to map the inducible NO synthase (Nos2). We report the chromosomal mapping of Nos2 to mouse chromosome 11, 3.3cM proximal to Scya2.

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Localization of Murine Macrophage Inducible Nitric Oxide Synthase to Mouse Chromosome 11

Abstract

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