Localization of mouse parathyroid hormone-like peptide gene (Pthlh) to distal chromosome 6 using interspecific backcross mice and in situ hybridization

Michael F Seldin, M. G. Mattei, G. N. Hendy

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The single copy parathyroid hormone-like peptide gene (Pthlh) was mapped to distal mouse chromosome 6 using genetic linkage analysis with a panel of DNA samples from interspecific backcross mice. In all 114 meiotic events examined, the Pth/h locus cosegregated with the locus for the Kirsten ras-2 gene (Kras-2) which was previously localized to distal mouse chromosome 6. In addition, Pthlh was localized to chromosome 6 band F-G and the mouse parathyroid hormone Pth was localized to chromosome 7 band F, by in situ hybridization. These studies confirm the previous localization of Pthlh to mouse chromosome 6 using somatic cell hybrids and show that the Pthlh/PTHLH locus is a part of a conserved linkage group between distal mouse chromosome 6 and the proximal segment of the short arm of human chromosome 12.

Original languageEnglish (US)
Pages (from-to)252-254
Number of pages3
JournalCytogenetics and Cell Genetics
Volume60
Issue number3-4
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology
  • Genetics

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