Localization of insulin-2 (Ins-2) and the obesity mutant tubby (tub) to distinct regions of mouse chromosome 7

Julie M. Jones; Miriam H. Meisler; Michael F Seldin; Barbara K. Lee; Eva M. Eicher

doi:10.1016/S0888-7543(05)80308-8

Localization of insulin-2 (Ins-2) and the obesity mutant tubby (tub) to distinct regions of mouse chromosome 7

Julie M. Jones, Miriam H. Meisler, Michael F Seldin, Barbara K. Lee, Eva M. Eicher

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A DNA mapping panel derived from an interspecific backcross was used to position the mouse insulin-2 locus (Ins-2) on Chromosome 7, near H19 (0/114 recombinants) and Th (1/114 recombinants). Ins-2 is part of a human-mouse conserved linkage group that includes Th, H19, and Igf-2. Analysis of segregation in the F2 generation from the cross C57BL/6J-tub/tub × CAST/Ei demonstrated that Ins-2 and the obesity mutant tubby (tub) are distinct loci, thus eliminating Ins-2 as a candidate gene for tub. These results also refine the estimated genetic distance between tub and Hbb to 2.4 ± 1.4 cM. The predicted location for a human homolog of tubby is HSA 11p15.

Original language	English (US)
Pages (from-to)	197-199
Number of pages	3
Journal	Genomics
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/S0888-7543(05)80308-8
State	Published - 1992
Externally published	Yes

ASJC Scopus subject areas

Genetics

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title = "Localization of insulin-2 (Ins-2) and the obesity mutant tubby (tub) to distinct regions of mouse chromosome 7",

abstract = "A DNA mapping panel derived from an interspecific backcross was used to position the mouse insulin-2 locus (Ins-2) on Chromosome 7, near H19 (0/114 recombinants) and Th (1/114 recombinants). Ins-2 is part of a human-mouse conserved linkage group that includes Th, H19, and Igf-2. Analysis of segregation in the F2 generation from the cross C57BL/6J-tub/tub × CAST/Ei demonstrated that Ins-2 and the obesity mutant tubby (tub) are distinct loci, thus eliminating Ins-2 as a candidate gene for tub. These results also refine the estimated genetic distance between tub and Hbb to 2.4 ± 1.4 cM. The predicted location for a human homolog of tubby is HSA 11p15.",

author = "Jones, {Julie M.} and Meisler, {Miriam H.} and Seldin, {Michael F} and Lee, {Barbara K.} and Eicher, {Eva M.}",

year = "1992",

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T1 - Localization of insulin-2 (Ins-2) and the obesity mutant tubby (tub) to distinct regions of mouse chromosome 7

AU - Jones, Julie M.

AU - Meisler, Miriam H.

AU - Seldin, Michael F

AU - Lee, Barbara K.

AU - Eicher, Eva M.

PY - 1992

Y1 - 1992

N2 - A DNA mapping panel derived from an interspecific backcross was used to position the mouse insulin-2 locus (Ins-2) on Chromosome 7, near H19 (0/114 recombinants) and Th (1/114 recombinants). Ins-2 is part of a human-mouse conserved linkage group that includes Th, H19, and Igf-2. Analysis of segregation in the F2 generation from the cross C57BL/6J-tub/tub × CAST/Ei demonstrated that Ins-2 and the obesity mutant tubby (tub) are distinct loci, thus eliminating Ins-2 as a candidate gene for tub. These results also refine the estimated genetic distance between tub and Hbb to 2.4 ± 1.4 cM. The predicted location for a human homolog of tubby is HSA 11p15.

AB - A DNA mapping panel derived from an interspecific backcross was used to position the mouse insulin-2 locus (Ins-2) on Chromosome 7, near H19 (0/114 recombinants) and Th (1/114 recombinants). Ins-2 is part of a human-mouse conserved linkage group that includes Th, H19, and Igf-2. Analysis of segregation in the F2 generation from the cross C57BL/6J-tub/tub × CAST/Ei demonstrated that Ins-2 and the obesity mutant tubby (tub) are distinct loci, thus eliminating Ins-2 as a candidate gene for tub. These results also refine the estimated genetic distance between tub and Hbb to 2.4 ± 1.4 cM. The predicted location for a human homolog of tubby is HSA 11p15.

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