Localization of amyloid β protein messenger RNA in brains from patients with Alzheimer's disease

Sina Bahmanyar, Gerald A. Higgins, Dmitry Goldgaber, David A. Lewis, John Morrison, Michael C. Wilson, Susarla K. Shankar, D. Carleton Gajdusek

Research output: Contribution to journalArticle

209 Citations (Scopus)

Abstract

The distribution of cells containing messenger RNA that encodes amyloid β protein was determined in hippocampi and in various cortical regions from cynomolgus monkeys, normal humans, and patients with Alzheimer's disease by in situ hybridization. Both 35S-labeled RNA antisense and sense probes to amyloid β protein messenger RNA were used to ensure specific hybridization. Messenger RNA for amyloid β protein was expressed in a subset of neurons n the prefontal cortex from monkeys, normal humans, and patients with Alzheimer's disease. This messenger RNA was also present in the neurons of all the hippocampal fields from monkeys, normal humans and, altough to a lesser extent in cornu ammonis 1, patients with Alzheimer's disease. The distribution of amyloid β protein messenger RNA was similar to that of the neurofibrillary tangles of Alzheimer's disease in some regions, but the messenger RNA was also expressed in other neurons that are not usually involved in the pathology of Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)77-80
Number of pages4
JournalScience
Volume237
Issue number4810
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

Fingerprint

Amyloidogenic Proteins
Alzheimer Disease
Messenger RNA
Brain
Neurons
Haplorhini
Hippocampus
Neurofibrillary Tangles
Macaca fascicularis
In Situ Hybridization
RNA
Pathology

ASJC Scopus subject areas

  • General

Cite this

Bahmanyar, S., Higgins, G. A., Goldgaber, D., Lewis, D. A., Morrison, J., Wilson, M. C., ... Gajdusek, D. C. (1987). Localization of amyloid β protein messenger RNA in brains from patients with Alzheimer's disease. Science, 237(4810), 77-80. https://doi.org/10.1126/science.3299701

Localization of amyloid β protein messenger RNA in brains from patients with Alzheimer's disease. / Bahmanyar, Sina; Higgins, Gerald A.; Goldgaber, Dmitry; Lewis, David A.; Morrison, John; Wilson, Michael C.; Shankar, Susarla K.; Gajdusek, D. Carleton.

In: Science, Vol. 237, No. 4810, 01.01.1987, p. 77-80.

Research output: Contribution to journalArticle

Bahmanyar, S, Higgins, GA, Goldgaber, D, Lewis, DA, Morrison, J, Wilson, MC, Shankar, SK & Gajdusek, DC 1987, 'Localization of amyloid β protein messenger RNA in brains from patients with Alzheimer's disease', Science, vol. 237, no. 4810, pp. 77-80. https://doi.org/10.1126/science.3299701
Bahmanyar, Sina ; Higgins, Gerald A. ; Goldgaber, Dmitry ; Lewis, David A. ; Morrison, John ; Wilson, Michael C. ; Shankar, Susarla K. ; Gajdusek, D. Carleton. / Localization of amyloid β protein messenger RNA in brains from patients with Alzheimer's disease. In: Science. 1987 ; Vol. 237, No. 4810. pp. 77-80.
@article{1d1f4dc7817448719afdfd48fdcbfc3c,
title = "Localization of amyloid β protein messenger RNA in brains from patients with Alzheimer's disease",
abstract = "The distribution of cells containing messenger RNA that encodes amyloid β protein was determined in hippocampi and in various cortical regions from cynomolgus monkeys, normal humans, and patients with Alzheimer's disease by in situ hybridization. Both 35S-labeled RNA antisense and sense probes to amyloid β protein messenger RNA were used to ensure specific hybridization. Messenger RNA for amyloid β protein was expressed in a subset of neurons n the prefontal cortex from monkeys, normal humans, and patients with Alzheimer's disease. This messenger RNA was also present in the neurons of all the hippocampal fields from monkeys, normal humans and, altough to a lesser extent in cornu ammonis 1, patients with Alzheimer's disease. The distribution of amyloid β protein messenger RNA was similar to that of the neurofibrillary tangles of Alzheimer's disease in some regions, but the messenger RNA was also expressed in other neurons that are not usually involved in the pathology of Alzheimer's disease.",
author = "Sina Bahmanyar and Higgins, {Gerald A.} and Dmitry Goldgaber and Lewis, {David A.} and John Morrison and Wilson, {Michael C.} and Shankar, {Susarla K.} and Gajdusek, {D. Carleton}",
year = "1987",
month = "1",
day = "1",
doi = "10.1126/science.3299701",
language = "English (US)",
volume = "237",
pages = "77--80",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "4810",

}

TY - JOUR

T1 - Localization of amyloid β protein messenger RNA in brains from patients with Alzheimer's disease

AU - Bahmanyar, Sina

AU - Higgins, Gerald A.

AU - Goldgaber, Dmitry

AU - Lewis, David A.

AU - Morrison, John

AU - Wilson, Michael C.

AU - Shankar, Susarla K.

AU - Gajdusek, D. Carleton

PY - 1987/1/1

Y1 - 1987/1/1

N2 - The distribution of cells containing messenger RNA that encodes amyloid β protein was determined in hippocampi and in various cortical regions from cynomolgus monkeys, normal humans, and patients with Alzheimer's disease by in situ hybridization. Both 35S-labeled RNA antisense and sense probes to amyloid β protein messenger RNA were used to ensure specific hybridization. Messenger RNA for amyloid β protein was expressed in a subset of neurons n the prefontal cortex from monkeys, normal humans, and patients with Alzheimer's disease. This messenger RNA was also present in the neurons of all the hippocampal fields from monkeys, normal humans and, altough to a lesser extent in cornu ammonis 1, patients with Alzheimer's disease. The distribution of amyloid β protein messenger RNA was similar to that of the neurofibrillary tangles of Alzheimer's disease in some regions, but the messenger RNA was also expressed in other neurons that are not usually involved in the pathology of Alzheimer's disease.

AB - The distribution of cells containing messenger RNA that encodes amyloid β protein was determined in hippocampi and in various cortical regions from cynomolgus monkeys, normal humans, and patients with Alzheimer's disease by in situ hybridization. Both 35S-labeled RNA antisense and sense probes to amyloid β protein messenger RNA were used to ensure specific hybridization. Messenger RNA for amyloid β protein was expressed in a subset of neurons n the prefontal cortex from monkeys, normal humans, and patients with Alzheimer's disease. This messenger RNA was also present in the neurons of all the hippocampal fields from monkeys, normal humans and, altough to a lesser extent in cornu ammonis 1, patients with Alzheimer's disease. The distribution of amyloid β protein messenger RNA was similar to that of the neurofibrillary tangles of Alzheimer's disease in some regions, but the messenger RNA was also expressed in other neurons that are not usually involved in the pathology of Alzheimer's disease.

UR - http://www.scopus.com/inward/record.url?scp=0023192563&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023192563&partnerID=8YFLogxK

U2 - 10.1126/science.3299701

DO - 10.1126/science.3299701

M3 - Article

C2 - 3299701

AN - SCOPUS:0023192563

VL - 237

SP - 77

EP - 80

JO - Science

JF - Science

SN - 0036-8075

IS - 4810

ER -