Localization and modulation of ErbB receptor tyrosine kinases

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

The ErbB family of receptor tyrosine kinases serves as a model for understanding the propagation of growth factor signals across the plasma membrane and the interpretation of those signals into a cellular response. Recent studies point to a critical role for the accumulation of ErbBs at specific cell-surface locations in the fidelity of ErbB signaling. The past year has witnessed significant advances in our understanding of the molecular mechanisms of ErbB localization and the role of PDZ-domain-containing proteins and cell-surface glycoproteins in directly modulating signaling through ErbBs.

Original languageEnglish (US)
Pages (from-to)125-130
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume13
Issue number2
DOIs
StatePublished - Apr 1 2001

ASJC Scopus subject areas

  • Cell Biology

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