Localization and modulation of ErbB receptor tyrosine kinases

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


The ErbB family of receptor tyrosine kinases serves as a model for understanding the propagation of growth factor signals across the plasma membrane and the interpretation of those signals into a cellular response. Recent studies point to a critical role for the accumulation of ErbBs at specific cell-surface locations in the fidelity of ErbB signaling. The past year has witnessed significant advances in our understanding of the molecular mechanisms of ErbB localization and the role of PDZ-domain-containing proteins and cell-surface glycoproteins in directly modulating signaling through ErbBs.

Original languageEnglish (US)
Pages (from-to)125-130
Number of pages6
JournalCurrent Opinion in Cell Biology
Issue number2
StatePublished - Apr 1 2001

ASJC Scopus subject areas

  • Cell Biology


Dive into the research topics of 'Localization and modulation of ErbB receptor tyrosine kinases'. Together they form a unique fingerprint.

Cite this