Local Regulation of L-Type Ca2+ Channel Sparklets in Arterial Smooth Muscle

Manuel F Navedo, Gregory C. Amberg

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

This review addresses the latest advances in our understanding of the regulation of a novel Ca2+ signal called L-type Ca2+ channel sparklets in arterial smooth muscle. L-type Ca2+ channel sparklets are elementary Ca2+ influx events produced by the opening of a single or a small cluster of L-type Ca2+ channels. These Ca2+ signals were first visualized in the vasculature in arterial smooth muscle cells. In these cells, L-type Ca2+ channel sparklets display two functionally distinct gating modalities that regulate local and global [Ca2+]i. The activity of L-type Ca2+ channel sparklets varies regionally within a cell depending on the dynamic activity of a cohort of protein kinases and phosphatases recruited to L-type Ca2+ channels in the arterial smooth muscle sarcolemma in a complex coordinated by the scaffolding molecule AKAP150. We also described a mechanism whereby clusters of L-type Ca2+ channels gate cooperatively to amplify intracellular Ca2+ signals with likely pathological consequences.

Original languageEnglish (US)
Pages (from-to)290-298
Number of pages9
JournalMicrocirculation
Volume20
Issue number4
DOIs
StatePublished - May 2013

Keywords

  • AKAP150
  • Coupled gating
  • Hypertension
  • TIRF microscopy
  • Type II diabetes

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

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