Local population structure and patterns of Western Hemisphere dispersal for Coccidioides spp., the fungal cause of valley fever

David M. Engelthaler, Chandler C. Roe, Crystal M. Hepp, Marcus Teixeira, Elizabeth M. Driebe, James M. Schupp, Lalitha Gade, Victor Waddell, Kenneth Komatsu, Eduardo Arathoon, Heidi Logemann, George Richard Thompson, Tom Chiller, Bridget Barker, Paul Keim, Anastasia P. Litvintseva

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Coccidioidomycosis (or valley fever) is a fungal disease with high morbidity and mortality that affects tens of thousands of people each year. This infection is caused by two sibling species, Coccidioides immitis and C. posadasii, which are endemic to specific arid locales throughout the Western Hemisphere, particularly the desert southwest of the United States. Recent epidemiological and population genetic data suggest that the geographic range of coccidioidomycosis is expanding, as new endemic clusters have been identified in the state of Washington, well outside the established endemic range. The genetic mechanisms and epidemiological consequences of this expansion are unknown and require better understanding of the population structure and evolutionary history of these pathogens. Here we performed multiple phylogenetic inference and population genomics analyses of 68 new and 18 previously published genomes. The results provide evidence of substantial population structure in C. posadasii and demonstrate the presence of distinct geographic clades in central and southern Arizona as well as dispersed populations in Texas, Mexico, South America, and Central America. Although a smaller number of C. immitis strains were included in the analyses, some evidence of phylogeographic structure was also detected in this species, which has been historically limited to California and Baja, Mexico. Bayesian analyses indicated that C. posadasii is the more ancient of the two species and that Arizona contains the most diverse subpopulations. We propose a southern Arizona-northern Mexico origin for C. posadasii and describe a pathway for dispersal and distribution out of this region. IMPORTANCE Coccidioidomycosis, or valley fever, is caused by the pathogenic fungi Coccidioides posadasii and C. immitis. The fungal species and disease are primarily found in the American desert southwest, with spotted distribution throughout the Western Hemisphere. Initial molecular studies suggested a likely anthropogenic movement of C. posadasii from North America to South America. Here we comparatively analyze eighty-six genomes of the two Coccidioides species and establish local and species-wide population structures to not only clarify the earlier dispersal hypothesis but also provide evidence of likely ancestral populations and patterns of dispersal for the known subpopulations of C. posadasii.

Original languageEnglish (US)
Article numbere00550-16
JournalmBio
Volume7
Issue number2
DOIs
StatePublished - Apr 26 2016

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Coccidioides
Coccidioidomycosis
Mexico
Mycoses
South America
Population
Genome
Central America
Metagenomics
Bayes Theorem
Population Genetics
North America
Fungi
Morbidity
Mortality
Infection

ASJC Scopus subject areas

  • Microbiology
  • Virology

Cite this

Engelthaler, D. M., Roe, C. C., Hepp, C. M., Teixeira, M., Driebe, E. M., Schupp, J. M., ... Litvintseva, A. P. (2016). Local population structure and patterns of Western Hemisphere dispersal for Coccidioides spp., the fungal cause of valley fever. mBio, 7(2), [e00550-16]. https://doi.org/10.1128/mBio.00550-16

Local population structure and patterns of Western Hemisphere dispersal for Coccidioides spp., the fungal cause of valley fever. / Engelthaler, David M.; Roe, Chandler C.; Hepp, Crystal M.; Teixeira, Marcus; Driebe, Elizabeth M.; Schupp, James M.; Gade, Lalitha; Waddell, Victor; Komatsu, Kenneth; Arathoon, Eduardo; Logemann, Heidi; Thompson, George Richard; Chiller, Tom; Barker, Bridget; Keim, Paul; Litvintseva, Anastasia P.

In: mBio, Vol. 7, No. 2, e00550-16, 26.04.2016.

Research output: Contribution to journalArticle

Engelthaler, DM, Roe, CC, Hepp, CM, Teixeira, M, Driebe, EM, Schupp, JM, Gade, L, Waddell, V, Komatsu, K, Arathoon, E, Logemann, H, Thompson, GR, Chiller, T, Barker, B, Keim, P & Litvintseva, AP 2016, 'Local population structure and patterns of Western Hemisphere dispersal for Coccidioides spp., the fungal cause of valley fever', mBio, vol. 7, no. 2, e00550-16. https://doi.org/10.1128/mBio.00550-16
Engelthaler, David M. ; Roe, Chandler C. ; Hepp, Crystal M. ; Teixeira, Marcus ; Driebe, Elizabeth M. ; Schupp, James M. ; Gade, Lalitha ; Waddell, Victor ; Komatsu, Kenneth ; Arathoon, Eduardo ; Logemann, Heidi ; Thompson, George Richard ; Chiller, Tom ; Barker, Bridget ; Keim, Paul ; Litvintseva, Anastasia P. / Local population structure and patterns of Western Hemisphere dispersal for Coccidioides spp., the fungal cause of valley fever. In: mBio. 2016 ; Vol. 7, No. 2.
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