Local cerebral glucose utilization in the symptomatic thiamine-deficient rat: Increases in fornix and pyramidal tract

Frank R Sharp, K. Evans, E. Bolger

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Local cerebral glucose utilization (LCGU) was measured in asymptomatic rats on a thiamine (B1)-deficient diet for 70 days and in symptomatic rats on a B1-deficient diet for 98 days. LCGU increased in postcommissural fornix (F), pyramidal tracts (P), and inferior internal capsule (CAI) of symptomatic, compared with asymptomatic B1-deficient rats but decreased in thalamic nuclei, auditory structures, and lesioned vestibular nuclei. B1 administration to symptomatic rats improved symptoms; decreased LCGU in F, P, and CAI; increased LCGU in the lesioned vestibular nuclei; but decreased LCGU in mammillary nuclei, anteroventral nucleus of thalamus, and medial raphe. The results indicate that B1 deficiency symptoms correlate with LCGU changes in F and P and vestibular nuclei.

Original languageEnglish (US)
Pages (from-to)808-814
Number of pages7
JournalNeurology
Volume32
Issue number8
StatePublished - 1982

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Local cerebral glucose utilization in the symptomatic thiamine-deficient rat: Increases in fornix and pyramidal tract'. Together they form a unique fingerprint.

  • Cite this