Local cerebral glucose metabolic rates in obsessive-compulsive disorder patients treated with clomipramine

Chawki Benkelfat, Thomas E Nordahl, William E. Semple, A. Catherine King, Dennis L. Murphy, Robert M. Cohen

Research output: Contribution to journalArticle

298 Scopus citations

Abstract

In a recent study, we reported abnormal local cerebral glucose metabolic rates in the orbital frontal cortex of patients with obsessive-compulsive disorder. Eight patients with obsessive-compulsive disorder scanned previously were scanned again during treatment with the tricyclic antidepressant clomipramine hydrochloride. Comparisons of local cerebral glucose metabolic rates for both groups showed a relative decrease in regions of the orbital frontal cortex and the left caudate, and an increase in other areas of the basal ganglia, including the right anterior putamen. When comparing patients who responded well to clomipramine with those who were either poor or partial responders, we found significant decreases only in the left caudate of patients who responded well to the drug. The present study suggests that clomipramine-induced Improvement in obsessive-compulsive symptoms is associated with a return of regional brain metabolism to a more normal level in regions of the orbital frontal cortex and the caudate nucleus.

Original languageEnglish (US)
Pages (from-to)840-848
Number of pages9
JournalArchives of General Psychiatry
Volume47
Issue number9
StatePublished - 1990

ASJC Scopus subject areas

  • Psychiatry and Mental health

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