Abstract
Toxoplasma gondii is among the most prevalent parasites worldwide, infecting many wild and domestic animals and causing zoonotic infections in humans. T. gondii differs substantially in its broad distribution from closely related parasites that typically have narrow, specialized host ranges. To elucidate the genetic basis for these differences, we compared the genomes of 62 globally distributed T. gondii isolates to several closely related coccidian parasites. Our findings reveal that tandem amplification and diversification of secretory pathogenesis determinants is the primary feature that distinguishes the closely related genomes of these biologically diverse parasites. We further show that the unusual population structure of T. gondii is characterized by clade-specific inheritance of large conserved haploblocks that are significantly enriched in tandemly clustered secretory pathogenesis determinants. The shared inheritance of these conserved haploblocks, which show a different ancestry than the genome as a whole, may thus influence transmission, host range and pathogenicity.
| Original language | English (US) |
|---|---|
| Article number | 10147 |
| Journal | Nature Communications |
| Volume | 7 |
| DOIs | |
| State | Published - Jan 7 2016 |
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ASJC Scopus subject areas
- Chemistry(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Physics and Astronomy(all)
Cite this
Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes. / Lorenzi, Hernan; Khan, Asis; Behnke, Michael S.; Namasivayam, Sivaranjani; Swapna, Lakshmipuram S.; Hadjithomas, Michalis; Karamycheva, Svetlana; Pinney, Deborah; Brunk, Brian P.; Ajioka, James W.; Ajzenberg, Daniel; Boothroyd, John C.; Boyle, Jon P.; Dardé, Marie L.; Diaz-Miranda, Maria A.; Dubey, Jitender P.; Fritz, Heather; Gennari, Solange M.; Gregory, Brian D.; Kim, Kami; Saeij, Jeroen; Su, Chunlei; White, Michael W.; Zhu, Xing Quan; Howe, Daniel K.; Rosenthal, Benjamin M.; Grigg, Michael E.; Parkinson, John; Liu, Liang; Kissinger, Jessica C.; Roos, David S.; Sibley, L. David.
In: Nature Communications, Vol. 7, 10147, 07.01.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes
AU - Lorenzi, Hernan
AU - Khan, Asis
AU - Behnke, Michael S.
AU - Namasivayam, Sivaranjani
AU - Swapna, Lakshmipuram S.
AU - Hadjithomas, Michalis
AU - Karamycheva, Svetlana
AU - Pinney, Deborah
AU - Brunk, Brian P.
AU - Ajioka, James W.
AU - Ajzenberg, Daniel
AU - Boothroyd, John C.
AU - Boyle, Jon P.
AU - Dardé, Marie L.
AU - Diaz-Miranda, Maria A.
AU - Dubey, Jitender P.
AU - Fritz, Heather
AU - Gennari, Solange M.
AU - Gregory, Brian D.
AU - Kim, Kami
AU - Saeij, Jeroen
AU - Su, Chunlei
AU - White, Michael W.
AU - Zhu, Xing Quan
AU - Howe, Daniel K.
AU - Rosenthal, Benjamin M.
AU - Grigg, Michael E.
AU - Parkinson, John
AU - Liu, Liang
AU - Kissinger, Jessica C.
AU - Roos, David S.
AU - Sibley, L. David
PY - 2016/1/7
Y1 - 2016/1/7
N2 - Toxoplasma gondii is among the most prevalent parasites worldwide, infecting many wild and domestic animals and causing zoonotic infections in humans. T. gondii differs substantially in its broad distribution from closely related parasites that typically have narrow, specialized host ranges. To elucidate the genetic basis for these differences, we compared the genomes of 62 globally distributed T. gondii isolates to several closely related coccidian parasites. Our findings reveal that tandem amplification and diversification of secretory pathogenesis determinants is the primary feature that distinguishes the closely related genomes of these biologically diverse parasites. We further show that the unusual population structure of T. gondii is characterized by clade-specific inheritance of large conserved haploblocks that are significantly enriched in tandemly clustered secretory pathogenesis determinants. The shared inheritance of these conserved haploblocks, which show a different ancestry than the genome as a whole, may thus influence transmission, host range and pathogenicity.
AB - Toxoplasma gondii is among the most prevalent parasites worldwide, infecting many wild and domestic animals and causing zoonotic infections in humans. T. gondii differs substantially in its broad distribution from closely related parasites that typically have narrow, specialized host ranges. To elucidate the genetic basis for these differences, we compared the genomes of 62 globally distributed T. gondii isolates to several closely related coccidian parasites. Our findings reveal that tandem amplification and diversification of secretory pathogenesis determinants is the primary feature that distinguishes the closely related genomes of these biologically diverse parasites. We further show that the unusual population structure of T. gondii is characterized by clade-specific inheritance of large conserved haploblocks that are significantly enriched in tandemly clustered secretory pathogenesis determinants. The shared inheritance of these conserved haploblocks, which show a different ancestry than the genome as a whole, may thus influence transmission, host range and pathogenicity.
UR - http://www.scopus.com/inward/record.url?scp=84954091677&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84954091677&partnerID=8YFLogxK
U2 - 10.1038/ncomms10147
DO - 10.1038/ncomms10147
M3 - Article
C2 - 26738725
AN - SCOPUS:84954091677
VL - 7
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 10147
ER -