Liver involvement in subjects with rheumatic disease

Carlo Selmi, Maria De Santis, M. Eric Gershwin

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The liver is often overlooked as a target organ, with pathology either secondary to an underlying disease or due to the toxicity of therapies and the medical complications of extrahepatic diseases. It is thus important for the clinical rheumatologist to be aware of the diagnostic procedure to monitor liver injury. Indeed, systemic rheumatologic diseases may be associated with liver abnormalities secondary to the presence of a coexisting autoimmune liver disease (particularly primary biliary cirrhosis or autoimmune hepatitis), the direct involvement of the liver parenchyma, or the impact of medical treatments (particularly methotrexate) on the liver. In addition, the rheumatologist should be aware of the impact of immunosuppressive agents on underlying viral infections, particularly viral hepatitis. We review herein the data on the role of the liver in the clinical management of systemic rheumatic diseases.

Original languageEnglish (US)
Article number226
JournalArthritis Research and Therapy
Volume13
Issue number3
DOIs
StatePublished - Jun 30 2011

Fingerprint

Rheumatic Diseases
Liver
Autoimmune Hepatitis
Biliary Liver Cirrhosis
Virus Diseases
Immunosuppressive Agents
Methotrexate
Hepatitis
Autoimmune Diseases
Liver Diseases
Pathology
Wounds and Injuries
Therapeutics

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy
  • Medicine(all)

Cite this

Liver involvement in subjects with rheumatic disease. / Selmi, Carlo; De Santis, Maria; Gershwin, M. Eric.

In: Arthritis Research and Therapy, Vol. 13, No. 3, 226, 30.06.2011.

Research output: Contribution to journalArticle

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