Liver denervation attenuates the hypophagia produced by an imbalanced amino acid diet

Larry L. Bellinger, Fred E. Williams, Quinton Rogers, Dorothy W. Gietzen

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We observed previously that totally liver denervated (TLD) rats consumed more of an imbalanced amino acid diet (IAAD) than sham-operated controls (CON). For the present study rats were either CON, TLD, had only the hepatic-vagal branch cut (HVX), or had all nerves on the hepatic artery and portal vein removed (HAPV) (n = 10-11). The rats were prefed a purified basal diet for 9 days then switched to an isoleucine IAAD for 7 days. On days 2-5 all experimental groups consumed more (p < 0.05) of the IAAD than the CON; they also showed less (p < 0.01) weight loss on days 3-7. This experiment showed that either total or partial liver denervations enhanced the intake of an IAAD compared to CON. However, when one considers the anatomical arrangement of the nerves and the surgery technique employed the vital neural pathway may involve the hepatic vagal branch.

Original languageEnglish (US)
Pages (from-to)925-929
Number of pages5
JournalPhysiology and Behavior
Volume59
Issue number4-5
DOIs
StatePublished - Jan 1 1996

Fingerprint

Denervation
Diet
Amino Acids
Liver
Neural Pathways
Hepatic Veins
Isoleucine
Hepatic Artery
Portal Vein
Weight Loss

Keywords

  • Amino acid deficiency
  • Amino acid imbalance
  • Body weight
  • Food intake
  • Rat

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Cite this

Liver denervation attenuates the hypophagia produced by an imbalanced amino acid diet. / Bellinger, Larry L.; Williams, Fred E.; Rogers, Quinton; Gietzen, Dorothy W.

In: Physiology and Behavior, Vol. 59, No. 4-5, 01.01.1996, p. 925-929.

Research output: Contribution to journalArticle

Bellinger, Larry L. ; Williams, Fred E. ; Rogers, Quinton ; Gietzen, Dorothy W. / Liver denervation attenuates the hypophagia produced by an imbalanced amino acid diet. In: Physiology and Behavior. 1996 ; Vol. 59, No. 4-5. pp. 925-929.
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