Live-Animal Epigenome Editing: Convergence of Novel Techniques

J. Antonio Gomez, Ulrika Beitnere, David Segal

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Epigenome editing refers to the generation of precise chromatin alterations and their effects on gene expression and cell biology. Until recently, much of the efforts in epigenome editing were limited to tissue culture models of disease. However, the convergence of techniques from different fields including mammalian genetics, virology, and CRISPR engineering is advancing epigenome editing into a new era. Researchers are increasingly embracing the use of multicellular model organisms to test the role of specific chromatin alterations in development and disease. The challenge of successful live-animal epigenomic editing will depend on a well-informed foundation of the current methodologies for cell-specific delivery and editing accuracy. Here we review the opportunities for basic research and therapeutic applications.

Original languageEnglish (US)
JournalTrends in Genetics
DOIs
StatePublished - Jan 1 2019

Keywords

  • animal models
  • cancer
  • CRISPR
  • delivery
  • epigenomic editing
  • neurodevelopment

ASJC Scopus subject areas

  • Genetics

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