Abstract
The architectonic features of abnormal cerebral cortex in a brain with lissencephaly and pachygyria suggest than neuronal migration was interrupted by cortical and subcortical laminar necrosis in the fourth fetal month. The severest cortical abnormality lies in the distal perfusion fields of the major cerebral arteries, while the normal areas are located in the proximal perfusion fields. These architectonic and topographic features suggest that intra-uterine hypoxia or perfusion failure may be a pathogenetic mechanism leading to lissencephaly and pachygyria.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-12 |
| Number of pages | 12 |
| Journal | Acta Neuropathologica |
| Volume | 31 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 1975 |
| Externally published | Yes |
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Keywords
- Hypoxia
- Laminar Necrosis
- Lissencephaly
- Neuronal Migration
- Pachygyria
- Perfusion Failure
ASJC Scopus subject areas
- Neuroscience(all)
- Pathology and Forensic Medicine
- Clinical Neurology
Cite this
Stewart, R. M., Richman, D. P., & Caviness, V. S. (1975). Lissencephaly and pachygyria - An architectonic and topographical analysis. Acta Neuropathologica, 31(1), 1-12. https://doi.org/10.1007/BF00696881