Lissencephaly and pachygyria - An architectonic and topographical analysis

R. Malcolm Stewart; David P Richman; Verne S. Caviness

doi:10.1007/BF00696881

Lissencephaly and pachygyria - An architectonic and topographical analysis

R. Malcolm Stewart, David P Richman, Verne S. Caviness

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Abstract

The architectonic features of abnormal cerebral cortex in a brain with lissencephaly and pachygyria suggest than neuronal migration was interrupted by cortical and subcortical laminar necrosis in the fourth fetal month. The severest cortical abnormality lies in the distal perfusion fields of the major cerebral arteries, while the normal areas are located in the proximal perfusion fields. These architectonic and topographic features suggest that intra-uterine hypoxia or perfusion failure may be a pathogenetic mechanism leading to lissencephaly and pachygyria.

Original language	English (US)
Pages (from-to)	1-12
Number of pages	12
Journal	Acta Neuropathologica
Volume	31
Issue number	1
DOIs	https://doi.org/10.1007/BF00696881
State	Published - Mar 1975
Externally published	Yes

Keywords

Hypoxia
Laminar Necrosis
Lissencephaly
Neuronal Migration
Pachygyria
Perfusion Failure

ASJC Scopus subject areas

Neuroscience(all)
Pathology and Forensic Medicine
Clinical Neurology

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AB - The architectonic features of abnormal cerebral cortex in a brain with lissencephaly and pachygyria suggest than neuronal migration was interrupted by cortical and subcortical laminar necrosis in the fourth fetal month. The severest cortical abnormality lies in the distal perfusion fields of the major cerebral arteries, while the normal areas are located in the proximal perfusion fields. These architectonic and topographic features suggest that intra-uterine hypoxia or perfusion failure may be a pathogenetic mechanism leading to lissencephaly and pachygyria.

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KW - Neuronal Migration

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KW - Perfusion Failure

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Lissencephaly and pachygyria - An architectonic and topographical analysis

Abstract

Keywords

ASJC Scopus subject areas

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