Lissencephaly and pachygyria - An architectonic and topographical analysis

R. Malcolm Stewart, David P Richman, Verne S. Caviness

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

The architectonic features of abnormal cerebral cortex in a brain with lissencephaly and pachygyria suggest than neuronal migration was interrupted by cortical and subcortical laminar necrosis in the fourth fetal month. The severest cortical abnormality lies in the distal perfusion fields of the major cerebral arteries, while the normal areas are located in the proximal perfusion fields. These architectonic and topographic features suggest that intra-uterine hypoxia or perfusion failure may be a pathogenetic mechanism leading to lissencephaly and pachygyria.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalActa Neuropathologica
Volume31
Issue number1
DOIs
StatePublished - Mar 1975
Externally publishedYes

Fingerprint

Lissencephaly
Perfusion
Cerebral Arteries
Cerebral Cortex
Necrosis
Brain

Keywords

  • Hypoxia
  • Laminar Necrosis
  • Lissencephaly
  • Neuronal Migration
  • Pachygyria
  • Perfusion Failure

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Lissencephaly and pachygyria - An architectonic and topographical analysis. / Stewart, R. Malcolm; Richman, David P; Caviness, Verne S.

In: Acta Neuropathologica, Vol. 31, No. 1, 03.1975, p. 1-12.

Research output: Contribution to journalArticle

Stewart, R. Malcolm ; Richman, David P ; Caviness, Verne S. / Lissencephaly and pachygyria - An architectonic and topographical analysis. In: Acta Neuropathologica. 1975 ; Vol. 31, No. 1. pp. 1-12.
@article{c6a37813a050486ebd75199a041ef7d4,
title = "Lissencephaly and pachygyria - An architectonic and topographical analysis",
abstract = "The architectonic features of abnormal cerebral cortex in a brain with lissencephaly and pachygyria suggest than neuronal migration was interrupted by cortical and subcortical laminar necrosis in the fourth fetal month. The severest cortical abnormality lies in the distal perfusion fields of the major cerebral arteries, while the normal areas are located in the proximal perfusion fields. These architectonic and topographic features suggest that intra-uterine hypoxia or perfusion failure may be a pathogenetic mechanism leading to lissencephaly and pachygyria.",
keywords = "Hypoxia, Laminar Necrosis, Lissencephaly, Neuronal Migration, Pachygyria, Perfusion Failure",
author = "Stewart, {R. Malcolm} and Richman, {David P} and Caviness, {Verne S.}",
year = "1975",
month = "3",
doi = "10.1007/BF00696881",
language = "English (US)",
volume = "31",
pages = "1--12",
journal = "Acta Neuropathologica",
issn = "0001-6322",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Lissencephaly and pachygyria - An architectonic and topographical analysis

AU - Stewart, R. Malcolm

AU - Richman, David P

AU - Caviness, Verne S.

PY - 1975/3

Y1 - 1975/3

N2 - The architectonic features of abnormal cerebral cortex in a brain with lissencephaly and pachygyria suggest than neuronal migration was interrupted by cortical and subcortical laminar necrosis in the fourth fetal month. The severest cortical abnormality lies in the distal perfusion fields of the major cerebral arteries, while the normal areas are located in the proximal perfusion fields. These architectonic and topographic features suggest that intra-uterine hypoxia or perfusion failure may be a pathogenetic mechanism leading to lissencephaly and pachygyria.

AB - The architectonic features of abnormal cerebral cortex in a brain with lissencephaly and pachygyria suggest than neuronal migration was interrupted by cortical and subcortical laminar necrosis in the fourth fetal month. The severest cortical abnormality lies in the distal perfusion fields of the major cerebral arteries, while the normal areas are located in the proximal perfusion fields. These architectonic and topographic features suggest that intra-uterine hypoxia or perfusion failure may be a pathogenetic mechanism leading to lissencephaly and pachygyria.

KW - Hypoxia

KW - Laminar Necrosis

KW - Lissencephaly

KW - Neuronal Migration

KW - Pachygyria

KW - Perfusion Failure

UR - http://www.scopus.com/inward/record.url?scp=0016411081&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016411081&partnerID=8YFLogxK

U2 - 10.1007/BF00696881

DO - 10.1007/BF00696881

M3 - Article

C2 - 1121923

AN - SCOPUS:0016411081

VL - 31

SP - 1

EP - 12

JO - Acta Neuropathologica

JF - Acta Neuropathologica

SN - 0001-6322

IS - 1

ER -