Abstract
The architectonic features of abnormal cerebral cortex in a brain with lissencephaly and pachygyria suggest than neuronal migration was interrupted by cortical and subcortical laminar necrosis in the fourth fetal month. The severest cortical abnormality lies in the distal perfusion fields of the major cerebral arteries, while the normal areas are located in the proximal perfusion fields. These architectonic and topographic features suggest that intra-uterine hypoxia or perfusion failure may be a pathogenetic mechanism leading to lissencephaly and pachygyria.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-12 |
| Number of pages | 12 |
| Journal | Acta Neuropathologica |
| Volume | 31 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 1975 |
| Externally published | Yes |
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Keywords
- Hypoxia
- Laminar Necrosis
- Lissencephaly
- Neuronal Migration
- Pachygyria
- Perfusion Failure
ASJC Scopus subject areas
- Neuroscience(all)
- Pathology and Forensic Medicine
- Clinical Neurology
Cite this
Lissencephaly and pachygyria - An architectonic and topographical analysis. / Stewart, R. Malcolm; Richman, David P; Caviness, Verne S.
In: Acta Neuropathologica, Vol. 31, No. 1, 03.1975, p. 1-12.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Lissencephaly and pachygyria - An architectonic and topographical analysis
AU - Stewart, R. Malcolm
AU - Richman, David P
AU - Caviness, Verne S.
PY - 1975/3
Y1 - 1975/3
N2 - The architectonic features of abnormal cerebral cortex in a brain with lissencephaly and pachygyria suggest than neuronal migration was interrupted by cortical and subcortical laminar necrosis in the fourth fetal month. The severest cortical abnormality lies in the distal perfusion fields of the major cerebral arteries, while the normal areas are located in the proximal perfusion fields. These architectonic and topographic features suggest that intra-uterine hypoxia or perfusion failure may be a pathogenetic mechanism leading to lissencephaly and pachygyria.
AB - The architectonic features of abnormal cerebral cortex in a brain with lissencephaly and pachygyria suggest than neuronal migration was interrupted by cortical and subcortical laminar necrosis in the fourth fetal month. The severest cortical abnormality lies in the distal perfusion fields of the major cerebral arteries, while the normal areas are located in the proximal perfusion fields. These architectonic and topographic features suggest that intra-uterine hypoxia or perfusion failure may be a pathogenetic mechanism leading to lissencephaly and pachygyria.
KW - Hypoxia
KW - Laminar Necrosis
KW - Lissencephaly
KW - Neuronal Migration
KW - Pachygyria
KW - Perfusion Failure
UR - http://www.scopus.com/inward/record.url?scp=0016411081&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016411081&partnerID=8YFLogxK
U2 - 10.1007/BF00696881
DO - 10.1007/BF00696881
M3 - Article
C2 - 1121923
AN - SCOPUS:0016411081
VL - 31
SP - 1
EP - 12
JO - Acta Neuropathologica
JF - Acta Neuropathologica
SN - 0001-6322
IS - 1
ER -