Lissencephaly and pachygyria - An architectonic and topographical analysis

R. Malcolm Stewart, David P Richman, Verne S. Caviness

Research output: Contribution to journalArticlepeer-review

118 Scopus citations


The architectonic features of abnormal cerebral cortex in a brain with lissencephaly and pachygyria suggest than neuronal migration was interrupted by cortical and subcortical laminar necrosis in the fourth fetal month. The severest cortical abnormality lies in the distal perfusion fields of the major cerebral arteries, while the normal areas are located in the proximal perfusion fields. These architectonic and topographic features suggest that intra-uterine hypoxia or perfusion failure may be a pathogenetic mechanism leading to lissencephaly and pachygyria.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalActa Neuropathologica
Issue number1
StatePublished - Mar 1975
Externally publishedYes


  • Hypoxia
  • Laminar Necrosis
  • Lissencephaly
  • Neuronal Migration
  • Pachygyria
  • Perfusion Failure

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology


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