Abstract
Plasma levels of lipoprotein(a), Lp(a), is an independent risk factor for cardiovascular disease. Lp(a) has many properties in common with low-density lipoprotein (LDL), including a cholesteryl ester-rich lipid core and the presence of one copy of apolipoprotein B-100; both apoB-100 and the lipid core are pro-atherogenic. In addition, Lp(a) contains a unique hydrophilic, carbohydrate-rich protein, apo(a), linked to apoB through a single disulfide bond connecting the C-terminal regions of the two proteins. The similarities between apolipoprotein(a), apo(a), and plasminogen has initiated numerous studies on the possible role of Lp(a) as a pro-thrombotic agent. Studies to date suggest that Lp(a) has antifibrinolytic and procoagulant properties. In this review, we summarize recent studies focused on the interaction between Lp(a) and platelets. Collectively, results to date illustrate that thrombogenicity associated with Lp(a) could be due to risk associated with the LDL moiety, with the apo(a) moiety, or from the combination of those in Lp(a). Present findings suggest that the various components of Lp(a) may impact to a varying degree on different underlying pathways involved in platelet activation and aggregation. On balance, results indicate an effect by Lp(a) on platelet function and future studies focused on specific Lp(a) components, such as the role of apo(a) and of the LDL-like lipid moiety, are needed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 314-321 |
| Number of pages | 8 |
| Journal | Pathophysiology of Haemostasis and Thrombosis |
| Volume | 35 |
| Issue number | 3-4 |
| DOIs | |
| State | Published - Jul 2006 |
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Keywords
- Atherosclerosis
- Cardiovascular disease
- Fibrinolysis
- Lipoprotein(a)
- Thrombocytes
- Thrombosis
ASJC Scopus subject areas
- Hematology
Cite this
Lipoprotein(a) and thrombocytes : Potential mechanisms underlying cardiovascular risk. / Discepolo, William; Wun, Theodore; Berglund, Lars.
In: Pathophysiology of Haemostasis and Thrombosis, Vol. 35, No. 3-4, 07.2006, p. 314-321.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lipoprotein(a) and thrombocytes
T2 - Potential mechanisms underlying cardiovascular risk
AU - Discepolo, William
AU - Wun, Theodore
AU - Berglund, Lars
PY - 2006/7
Y1 - 2006/7
N2 - Plasma levels of lipoprotein(a), Lp(a), is an independent risk factor for cardiovascular disease. Lp(a) has many properties in common with low-density lipoprotein (LDL), including a cholesteryl ester-rich lipid core and the presence of one copy of apolipoprotein B-100; both apoB-100 and the lipid core are pro-atherogenic. In addition, Lp(a) contains a unique hydrophilic, carbohydrate-rich protein, apo(a), linked to apoB through a single disulfide bond connecting the C-terminal regions of the two proteins. The similarities between apolipoprotein(a), apo(a), and plasminogen has initiated numerous studies on the possible role of Lp(a) as a pro-thrombotic agent. Studies to date suggest that Lp(a) has antifibrinolytic and procoagulant properties. In this review, we summarize recent studies focused on the interaction between Lp(a) and platelets. Collectively, results to date illustrate that thrombogenicity associated with Lp(a) could be due to risk associated with the LDL moiety, with the apo(a) moiety, or from the combination of those in Lp(a). Present findings suggest that the various components of Lp(a) may impact to a varying degree on different underlying pathways involved in platelet activation and aggregation. On balance, results indicate an effect by Lp(a) on platelet function and future studies focused on specific Lp(a) components, such as the role of apo(a) and of the LDL-like lipid moiety, are needed.
AB - Plasma levels of lipoprotein(a), Lp(a), is an independent risk factor for cardiovascular disease. Lp(a) has many properties in common with low-density lipoprotein (LDL), including a cholesteryl ester-rich lipid core and the presence of one copy of apolipoprotein B-100; both apoB-100 and the lipid core are pro-atherogenic. In addition, Lp(a) contains a unique hydrophilic, carbohydrate-rich protein, apo(a), linked to apoB through a single disulfide bond connecting the C-terminal regions of the two proteins. The similarities between apolipoprotein(a), apo(a), and plasminogen has initiated numerous studies on the possible role of Lp(a) as a pro-thrombotic agent. Studies to date suggest that Lp(a) has antifibrinolytic and procoagulant properties. In this review, we summarize recent studies focused on the interaction between Lp(a) and platelets. Collectively, results to date illustrate that thrombogenicity associated with Lp(a) could be due to risk associated with the LDL moiety, with the apo(a) moiety, or from the combination of those in Lp(a). Present findings suggest that the various components of Lp(a) may impact to a varying degree on different underlying pathways involved in platelet activation and aggregation. On balance, results indicate an effect by Lp(a) on platelet function and future studies focused on specific Lp(a) components, such as the role of apo(a) and of the LDL-like lipid moiety, are needed.
KW - Atherosclerosis
KW - Cardiovascular disease
KW - Fibrinolysis
KW - Lipoprotein(a)
KW - Thrombocytes
KW - Thrombosis
UR - http://www.scopus.com/inward/record.url?scp=33746627292&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33746627292&partnerID=8YFLogxK
U2 - 10.1159/000093224
DO - 10.1159/000093224
M3 - Article
C2 - 16877880
AN - SCOPUS:33746627292
VL - 35
SP - 314
EP - 321
JO - Pathophysiology of Haemostasis and Thrombosis
JF - Pathophysiology of Haemostasis and Thrombosis
SN - 1424-8832
IS - 3-4
ER -