Lipoprotein lipase does not increase significantly in the postprandial plasma

Nobuyoshi Ishiyama, Kouji Sakamaki, Younosuke Shimomura, Kazuhiko Kotani, Kokoro Tsuzaki, Naoki Sakane, Kazuya Miyashita, Isao Fukamachi, Junji Kobayashi, Kimber L. Stanhope, Peter J. Havel, Keiko Kamachi, Akira Tanaka, Yoshiharu Tokita, Tetsuo Machida, Masami Murakami, Katsuyuki Nakajima

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Background Previous reports have shown that lipoprotein lipase (LPL) activity significantly increases in the postprandial plasma associated with the increase of TG-rich lipoproteins. Therefore, we have reexamined those relationships using newly developed LPL assay with the different kinds of food intake. Methods Standard meal (n = 81), 50 g of fat (n = 54), 75 g of glucose (n = 25) and cookie (25 g fat and 75 g carbohydrate fat) (n = 28) were administered in generally healthy volunteers. Plasma LPL, HTGL and TC, TG, LDL-C, HDL-C, RLP-C and RLP-TG were determined at subsequent withdrawal after the food intake. Results Plasma TG, RLP-C and RLP-TG were significantly increased at 8 PM (2 h after dinner of standard meal) compared with 8 AM before breakfast within the same day. Also those parameters were significantly increased in 2–6 h after fat load. However, the concentrations and activities of LPL and HTGL did not significantly increase in association with an increase in the TG and remnant lipoproteins. Also LPL concentration did not significantly increase after glucose and “cookie test” within 4 h. Conclusion No significant increase of LPL activity was found at CM and VLDL overload after different kinds of food intake when reexamined by newly developed assay for LPL activity and concentration.

Original languageEnglish (US)
Pages (from-to)204-210
Number of pages7
JournalClinica Chimica Acta
StatePublished - Jan 1 2017


  • Chylomicrons
  • Hepatic triglyceride lipase
  • Lipoprotein lipase
  • Remnant lipoproteins
  • RLP-C
  • RLP-TG
  • Triglycerides
  • Very low density lipoproteins

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical


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