Lipoprotein lipase activity and cellularity in brown and white adipose tissue in Zucker obese rats

Barbara A Horwitz, Toshiki Inokuchi, Steven J. Wickler, Judith S. Stern

Research output: Contribution to journalArticle

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Abstract

The genetically obese adult Zucker rat (fafa) exhibits reduced thermogenesis when stimulated by physiological agents (cold, catecholamines). Recent evidence suggests that this thermogenic defect may be important in the manifestation of the animal's obesity and that it reflects a reduced thermogenic contribution from brown adipose tissue, the major nonshivering thermogenic site in many mammals. The present study describes the effects of the obese genotype on brown (and white) adipocyte size, number, and lipid content and tissue lipoprotein lipase (LPL) activity. In the obese rats, brown fat depots were increased in mass. This increase could be accounted for by brown fat hypertrophy (due primarily to an increase in the amount of triglyceride present in each cell) rather than hyperplasia (there being no increase in the number of brown fat cells). In addition, unlike the situation in white fat, the brown fat from the obese rats did not exhibit higher LPL activity than did the brown fat from their lean littermates. This absence of an increased capacity for triglyceride uptake, coupled with the greater amount of triglyceride per brown adipocyte, is consistent with a reduction of triglyceride oxidation (and, thus, heat production) in the cells from the obese (v the lean) rats.

Original languageEnglish (US)
Pages (from-to)354-357
Number of pages4
JournalMetabolism
Volume33
Issue number4
DOIs
StatePublished - 1984

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Zucker Rats
White Adipose Tissue
Brown Adipose Tissue
Lipoprotein Lipase
Brown Adipocytes
Triglycerides
Thermogenesis
White Adipocytes
Hypertrophy
Catecholamines
Hyperplasia
Mammals
Obesity
Genotype
Lipids

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Lipoprotein lipase activity and cellularity in brown and white adipose tissue in Zucker obese rats. / Horwitz, Barbara A; Inokuchi, Toshiki; Wickler, Steven J.; Stern, Judith S.

In: Metabolism, Vol. 33, No. 4, 1984, p. 354-357.

Research output: Contribution to journalArticle

Horwitz, Barbara A ; Inokuchi, Toshiki ; Wickler, Steven J. ; Stern, Judith S. / Lipoprotein lipase activity and cellularity in brown and white adipose tissue in Zucker obese rats. In: Metabolism. 1984 ; Vol. 33, No. 4. pp. 354-357.
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