Lipoprotein (a): Impact by ethnicity and environmental and medical conditions

Research output: Contribution to journalReview article

34 Citations (Scopus)

Abstract

Levels of lipoprotein (a) [Lp(a)], a complex between an LDL-like lipid moiety containing one copy of apoB, and apo(a), a plasminogen-derived carbohydrate-rich hydrophilic protein, are primarily genetically regulated. Although stable intra-individually, Lp(a) levels have a skewed distribution inter-individually and are strongly impacted by a size polymorphism of the LPA gene, resulting in a variable number of kringle IV (KIV) units, a key motif of apo(a). The variation in KIV units is a strong predictor of plasma Lp(a) levels resulting in stable plasma levels across the lifespan. Studies have demonstrated pronounced differences across ethnicities with regard to Lp(a) levels and some of this difference, but not all of it, can be explained by genetic variations across ethnic groups. Increasing evidence suggests that age, sex, and hormonal impact may have a modest modulatory influence on Lp(a) levels. Among clinical conditions, Lp(a) levels are reported to be affected by kidney and liver diseases.

Original languageEnglish (US)
Pages (from-to)1111-1125
Number of pages15
JournalJournal of Lipid Research
Volume57
Issue number7
DOIs
StatePublished - Jul 1 2016

Fingerprint

Lipoprotein(a)
Kringles
Plasmas
Plasminogen
Kidney Diseases
Apolipoproteins B
Polymorphism
Ethnic Groups
Liver
Liver Diseases
Genes
Carbohydrates
Lipids
Proteins

Keywords

  • Apolipoprotein (a) size
  • Demographic and clinical characteristics
  • Diabetes
  • Genetics
  • Kidney and liver disease
  • Supplementary key words populations

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Cell Biology

Cite this

Lipoprotein (a) : Impact by ethnicity and environmental and medical conditions. / Byambaa, Enkhmaa; Erdembileg, Anuurad; Berglund, Lars.

In: Journal of Lipid Research, Vol. 57, No. 7, 01.07.2016, p. 1111-1125.

Research output: Contribution to journalReview article

@article{4044556b02a54da9b3ed81be4df28640,
title = "Lipoprotein (a): Impact by ethnicity and environmental and medical conditions",
abstract = "Levels of lipoprotein (a) [Lp(a)], a complex between an LDL-like lipid moiety containing one copy of apoB, and apo(a), a plasminogen-derived carbohydrate-rich hydrophilic protein, are primarily genetically regulated. Although stable intra-individually, Lp(a) levels have a skewed distribution inter-individually and are strongly impacted by a size polymorphism of the LPA gene, resulting in a variable number of kringle IV (KIV) units, a key motif of apo(a). The variation in KIV units is a strong predictor of plasma Lp(a) levels resulting in stable plasma levels across the lifespan. Studies have demonstrated pronounced differences across ethnicities with regard to Lp(a) levels and some of this difference, but not all of it, can be explained by genetic variations across ethnic groups. Increasing evidence suggests that age, sex, and hormonal impact may have a modest modulatory influence on Lp(a) levels. Among clinical conditions, Lp(a) levels are reported to be affected by kidney and liver diseases.",
keywords = "Apolipoprotein (a) size, Demographic and clinical characteristics, Diabetes, Genetics, Kidney and liver disease, Supplementary key words populations",
author = "Enkhmaa Byambaa and Anuurad Erdembileg and Lars Berglund",
year = "2016",
month = "7",
day = "1",
doi = "10.1194/jlr.R051904",
language = "English (US)",
volume = "57",
pages = "1111--1125",
journal = "Journal of Lipid Research",
issn = "0022-2275",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "7",

}

TY - JOUR

T1 - Lipoprotein (a)

T2 - Impact by ethnicity and environmental and medical conditions

AU - Byambaa, Enkhmaa

AU - Erdembileg, Anuurad

AU - Berglund, Lars

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Levels of lipoprotein (a) [Lp(a)], a complex between an LDL-like lipid moiety containing one copy of apoB, and apo(a), a plasminogen-derived carbohydrate-rich hydrophilic protein, are primarily genetically regulated. Although stable intra-individually, Lp(a) levels have a skewed distribution inter-individually and are strongly impacted by a size polymorphism of the LPA gene, resulting in a variable number of kringle IV (KIV) units, a key motif of apo(a). The variation in KIV units is a strong predictor of plasma Lp(a) levels resulting in stable plasma levels across the lifespan. Studies have demonstrated pronounced differences across ethnicities with regard to Lp(a) levels and some of this difference, but not all of it, can be explained by genetic variations across ethnic groups. Increasing evidence suggests that age, sex, and hormonal impact may have a modest modulatory influence on Lp(a) levels. Among clinical conditions, Lp(a) levels are reported to be affected by kidney and liver diseases.

AB - Levels of lipoprotein (a) [Lp(a)], a complex between an LDL-like lipid moiety containing one copy of apoB, and apo(a), a plasminogen-derived carbohydrate-rich hydrophilic protein, are primarily genetically regulated. Although stable intra-individually, Lp(a) levels have a skewed distribution inter-individually and are strongly impacted by a size polymorphism of the LPA gene, resulting in a variable number of kringle IV (KIV) units, a key motif of apo(a). The variation in KIV units is a strong predictor of plasma Lp(a) levels resulting in stable plasma levels across the lifespan. Studies have demonstrated pronounced differences across ethnicities with regard to Lp(a) levels and some of this difference, but not all of it, can be explained by genetic variations across ethnic groups. Increasing evidence suggests that age, sex, and hormonal impact may have a modest modulatory influence on Lp(a) levels. Among clinical conditions, Lp(a) levels are reported to be affected by kidney and liver diseases.

KW - Apolipoprotein (a) size

KW - Demographic and clinical characteristics

KW - Diabetes

KW - Genetics

KW - Kidney and liver disease

KW - Supplementary key words populations

UR - http://www.scopus.com/inward/record.url?scp=84977137793&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84977137793&partnerID=8YFLogxK

U2 - 10.1194/jlr.R051904

DO - 10.1194/jlr.R051904

M3 - Review article

C2 - 26637279

AN - SCOPUS:84977137793

VL - 57

SP - 1111

EP - 1125

JO - Journal of Lipid Research

JF - Journal of Lipid Research

SN - 0022-2275

IS - 7

ER -