Lipoic acid is 10 times more toxic in cats than reported in humans, dogs or rats

A. S. Hill, J. A. Werner, Quinton Rogers, S. L. O'Neill, Mary M Christopher

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The antioxidant lipoic acid (LA) is administered to humans and pets. We described acute toxicity and maximum tolerated dose (MTD) of LA in cats. In progression, 10 healthy adult male cats received orally 60 (high), 30 (low), or 0 mg LA/kg (control). Serum enzyme activities and concentrations of bile acids, ammonia, amino acids (AA), LA and dihydrolipoic acid (DHLA) were measured, and tissues examined microscopically. Significant clinical toxicity with changes in ammonia and AA concentrations occurred in all high-dose cats. Oral LA produced hepatocellular toxicity and MTD was <30 mg/kg in cats.

Original languageEnglish (US)
Pages (from-to)150-156
Number of pages7
JournalJournal of Animal Physiology and Animal Nutrition
Volume88
Issue number3-4
StatePublished - Apr 2004

Fingerprint

lipoic acid
Thioctic Acid
Poisons
Cats
Dogs
cats
dogs
rats
Maximum Tolerated Dose
Ammonia
ammonia
dosage
toxicity
Amino Acids
amino acids
Pets
bile acids
acute toxicity
Bile Acids and Salts
pets

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Lipoic acid is 10 times more toxic in cats than reported in humans, dogs or rats. / Hill, A. S.; Werner, J. A.; Rogers, Quinton; O'Neill, S. L.; Christopher, Mary M.

In: Journal of Animal Physiology and Animal Nutrition, Vol. 88, No. 3-4, 04.2004, p. 150-156.

Research output: Contribution to journalArticle

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