Lipoic acid is 10 times more toxic in cats than reported in humans, dogs or rats

A. S. Hill, J. A. Werner, Quinton Rogers, S. L. O'Neill, Mary M Christopher

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

The antioxidant lipoic acid (LA) is administered to humans and pets. We described acute toxicity and maximum tolerated dose (MTD) of LA in cats. In progression, 10 healthy adult male cats received orally 60 (high), 30 (low), or 0 mg LA/kg (control). Serum enzyme activities and concentrations of bile acids, ammonia, amino acids (AA), LA and dihydrolipoic acid (DHLA) were measured, and tissues examined microscopically. Significant clinical toxicity with changes in ammonia and AA concentrations occurred in all high-dose cats. Oral LA produced hepatocellular toxicity and MTD was <30 mg/kg in cats.

Original languageEnglish (US)
Pages (from-to)150-156
Number of pages7
JournalJournal of Animal Physiology and Animal Nutrition
Volume88
Issue number3-4
StatePublished - Apr 2004

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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