TY - JOUR
T1 - Lipids and diabetic retinopathy
AU - Modjtahedi, Bobeck S.
AU - Bose, Namrata
AU - Papakostas, Thanos D.
AU - Morse, Lawrence S
AU - Vavvas, Demetrios G.
AU - Kishan, Amar U.
PY - 2016/3/3
Y1 - 2016/3/3
N2 - The relationship between lipids and the development and/or severity of diabetic retinopathy (DR) is complex. Large epidemiologic studies suggest an inconsistent and overall modest association between serum triglycerides or major cholesterol species and the severity of DR; however, certain specific lipoprotein species may have stronger associations with DR severity, suggesting a pathophysiological role for lipoproteins analogous to that seen in atherosclerosis. In this lipoprotein-mediated DR pathogenesis model, damage to the blood-retinal barrier allows extravasation of lipoprotein species, which are modified in the intraretinal environment, creating substantial local damage. Additionally, hypolipidemic therapy with statins and fibrates - particularly the latter - have been shown to modulate DR in large-scale studies. Since serum lipid profile changes do not necessarily correlate with DR modulation, the efficacy of these agents may be due to their tissue-specific changes in lipoproteins and/or their anti-inflammatory, antioxidative, antiangiogenic, and antiapoptotic functions.
AB - The relationship between lipids and the development and/or severity of diabetic retinopathy (DR) is complex. Large epidemiologic studies suggest an inconsistent and overall modest association between serum triglycerides or major cholesterol species and the severity of DR; however, certain specific lipoprotein species may have stronger associations with DR severity, suggesting a pathophysiological role for lipoproteins analogous to that seen in atherosclerosis. In this lipoprotein-mediated DR pathogenesis model, damage to the blood-retinal barrier allows extravasation of lipoprotein species, which are modified in the intraretinal environment, creating substantial local damage. Additionally, hypolipidemic therapy with statins and fibrates - particularly the latter - have been shown to modulate DR in large-scale studies. Since serum lipid profile changes do not necessarily correlate with DR modulation, the efficacy of these agents may be due to their tissue-specific changes in lipoproteins and/or their anti-inflammatory, antioxidative, antiangiogenic, and antiapoptotic functions.
KW - Diabetic retinopathy
KW - Fibrates
KW - Lipid metabolism
KW - Lipoprotein
KW - Statins
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U2 - 10.3109/08820538.2015.1114869
DO - 10.3109/08820538.2015.1114869
M3 - Review article
C2 - 26959124
AN - SCOPUS:84962145337
VL - 31
SP - 10
EP - 18
JO - Seminars in Ophthalmology
JF - Seminars in Ophthalmology
SN - 0882-0538
IS - 1-2
ER -