Abstract
Given the considerable public health burden imposed by age-related macular degeneration (AMD), much effort has been directed towards elucidating principles of pathogenesis in order to identify risk factors and develop preventive measures and treatments. Together with epidemiological evidence linking cardiovascular risk factors with AMD risk and basic science work examining the role of lipid metabolism in AMD, numerous human studies have assayed a potential relationship between dietary lipids and the development of AMD. We examine the evidence for a role for lipid metabolism in AMD, highlighting key basic biochemical principles, work in animal models, and relevant human studies. The topics of lipoprotein modulation and omega-3 fatty acid intake receive special attention from both a basic science and clinical study standpoint. The evidence suggests that consumption of omega-3 fatty acids, perhaps in concert with antioxidants, may constitute a rational preventative strategy against AMD development, though, absent an appropriately developed double-blind, randomized control trial, insufficient data exist to recommend implementation in the clinical setting at this time.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 195-213 |
| Number of pages | 19 |
| Journal | Survey of Ophthalmology |
| Volume | 56 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 2011 |
Fingerprint
Keywords
- Age-related macular degeneration
- Cholesterol
- Diet
- Docosahexaenoic acid
- Eicosapentaenoic acid
- Human
- Lipids
- Metabolism
- Omega-3
- Statin
ASJC Scopus subject areas
- Ophthalmology
Cite this
Lipids and Age-related Macular Degeneration. / Kishan, Amar U.; Modjtahedi, Bobeck S.; Martins, Elisabeth N.; Modjtahedi, Sara P.; Morse, Lawrence S.
In: Survey of Ophthalmology, Vol. 56, No. 3, 05.2011, p. 195-213.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lipids and Age-related Macular Degeneration
AU - Kishan, Amar U.
AU - Modjtahedi, Bobeck S.
AU - Martins, Elisabeth N.
AU - Modjtahedi, Sara P.
AU - Morse, Lawrence S
PY - 2011/5
Y1 - 2011/5
N2 - Given the considerable public health burden imposed by age-related macular degeneration (AMD), much effort has been directed towards elucidating principles of pathogenesis in order to identify risk factors and develop preventive measures and treatments. Together with epidemiological evidence linking cardiovascular risk factors with AMD risk and basic science work examining the role of lipid metabolism in AMD, numerous human studies have assayed a potential relationship between dietary lipids and the development of AMD. We examine the evidence for a role for lipid metabolism in AMD, highlighting key basic biochemical principles, work in animal models, and relevant human studies. The topics of lipoprotein modulation and omega-3 fatty acid intake receive special attention from both a basic science and clinical study standpoint. The evidence suggests that consumption of omega-3 fatty acids, perhaps in concert with antioxidants, may constitute a rational preventative strategy against AMD development, though, absent an appropriately developed double-blind, randomized control trial, insufficient data exist to recommend implementation in the clinical setting at this time.
AB - Given the considerable public health burden imposed by age-related macular degeneration (AMD), much effort has been directed towards elucidating principles of pathogenesis in order to identify risk factors and develop preventive measures and treatments. Together with epidemiological evidence linking cardiovascular risk factors with AMD risk and basic science work examining the role of lipid metabolism in AMD, numerous human studies have assayed a potential relationship between dietary lipids and the development of AMD. We examine the evidence for a role for lipid metabolism in AMD, highlighting key basic biochemical principles, work in animal models, and relevant human studies. The topics of lipoprotein modulation and omega-3 fatty acid intake receive special attention from both a basic science and clinical study standpoint. The evidence suggests that consumption of omega-3 fatty acids, perhaps in concert with antioxidants, may constitute a rational preventative strategy against AMD development, though, absent an appropriately developed double-blind, randomized control trial, insufficient data exist to recommend implementation in the clinical setting at this time.
KW - Age-related macular degeneration
KW - Cholesterol
KW - Diet
KW - Docosahexaenoic acid
KW - Eicosapentaenoic acid
KW - Human
KW - Lipids
KW - Metabolism
KW - Omega-3
KW - Statin
UR - http://www.scopus.com/inward/record.url?scp=79954630102&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79954630102&partnerID=8YFLogxK
U2 - 10.1016/j.survophthal.2010.08.008
DO - 10.1016/j.survophthal.2010.08.008
M3 - Article
C2 - 21439604
AN - SCOPUS:79954630102
VL - 56
SP - 195
EP - 213
JO - Survey of Ophthalmology
JF - Survey of Ophthalmology
SN - 0039-6257
IS - 3
ER -