Lipidomics and lipid profiling in metabolomics

J. Bruce German, Laura A. Gillies, Jennifer T. Smilowitz, Angela M. Zivkovic, Steven M. Watkins

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: The field of metabolomics is extending the principles of genomics into cellular and organism metabolism and driving a revolution in lipid biochemistry, physiology and nutrition. Lipids studied using metabolomic approaches - lipidomics - are an ideal subject for metabolomic measurements. RECENT FINDINGS: Lipids are small molecules that share common physical and chemical properties as a class, whose presence and abundance are key to much of metabolic regulation, from subcellular compartments to whole body energy control and signaling. Furthermore, by measuring changes in lipid concentrations, scientists are gaining a more detailed understanding of biochemistry and thus annotating genomes, but also understanding genetic polymorphisms and the postgenetic effects induced by drugs, foods and toxins. SUMMARY: Although in its infancy - there are fewer than 200 total articles on lipidomics and metabolomics focusing on lipids - the field of metabolomics is beginning to deliver on its promise to revolutionize lipid and metabolic disease research.

Original languageEnglish (US)
Pages (from-to)66-71
Number of pages6
JournalCurrent Opinion in Lipidology
Volume18
Issue number1
DOIs
StatePublished - Feb 2007

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Metabolomics
Lipids
Biochemistry
Nutritional Physiological Phenomena
Metabolic Diseases
Physiology
Genetic Polymorphisms
Nutrition
Genomics
Polymorphism
Metabolism
Power control
Chemical properties
Physical properties
Genes
Genome
Food
Molecules
Research
Pharmaceutical Preparations

Keywords

  • Drug development
  • Lipidomics
  • Metabolites
  • Metabolomics
  • Personalized medicine
  • Profiling

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

German, J. B., Gillies, L. A., Smilowitz, J. T., Zivkovic, A. M., & Watkins, S. M. (2007). Lipidomics and lipid profiling in metabolomics. Current Opinion in Lipidology, 18(1), 66-71. https://doi.org/10.1097/MOL.0b013e328012d911

Lipidomics and lipid profiling in metabolomics. / German, J. Bruce; Gillies, Laura A.; Smilowitz, Jennifer T.; Zivkovic, Angela M.; Watkins, Steven M.

In: Current Opinion in Lipidology, Vol. 18, No. 1, 02.2007, p. 66-71.

Research output: Contribution to journalArticle

German, JB, Gillies, LA, Smilowitz, JT, Zivkovic, AM & Watkins, SM 2007, 'Lipidomics and lipid profiling in metabolomics', Current Opinion in Lipidology, vol. 18, no. 1, pp. 66-71. https://doi.org/10.1097/MOL.0b013e328012d911
German JB, Gillies LA, Smilowitz JT, Zivkovic AM, Watkins SM. Lipidomics and lipid profiling in metabolomics. Current Opinion in Lipidology. 2007 Feb;18(1):66-71. https://doi.org/10.1097/MOL.0b013e328012d911
German, J. Bruce ; Gillies, Laura A. ; Smilowitz, Jennifer T. ; Zivkovic, Angela M. ; Watkins, Steven M. / Lipidomics and lipid profiling in metabolomics. In: Current Opinion in Lipidology. 2007 ; Vol. 18, No. 1. pp. 66-71.
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