Lipidomics and lipid profiling in metabolomics

J. Bruce German, Laura A. Gillies, Jennifer T. Smilowitz, Angela M. Zivkovic, Steven M. Watkins

Research output: Contribution to journalArticle

106 Scopus citations

Abstract

PURPOSE OF REVIEW: The field of metabolomics is extending the principles of genomics into cellular and organism metabolism and driving a revolution in lipid biochemistry, physiology and nutrition. Lipids studied using metabolomic approaches - lipidomics - are an ideal subject for metabolomic measurements. RECENT FINDINGS: Lipids are small molecules that share common physical and chemical properties as a class, whose presence and abundance are key to much of metabolic regulation, from subcellular compartments to whole body energy control and signaling. Furthermore, by measuring changes in lipid concentrations, scientists are gaining a more detailed understanding of biochemistry and thus annotating genomes, but also understanding genetic polymorphisms and the postgenetic effects induced by drugs, foods and toxins. SUMMARY: Although in its infancy - there are fewer than 200 total articles on lipidomics and metabolomics focusing on lipids - the field of metabolomics is beginning to deliver on its promise to revolutionize lipid and metabolic disease research.

Original languageEnglish (US)
Pages (from-to)66-71
Number of pages6
JournalCurrent Opinion in Lipidology
Volume18
Issue number1
DOIs
StatePublished - Feb 2007

Keywords

  • Drug development
  • Lipidomics
  • Metabolites
  • Metabolomics
  • Personalized medicine
  • Profiling

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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