In 21-day-old crinkled and noncrinkled mice, the brain lipids were analyzed since myelin formation is most active between 15 and 30 days after birth. For comparison, brain lipid content was measured and histologic examination was made in adult brains when myelin production was essentially complete. The brain lipid composition and its histology on both groups of mice, fed a normal diet, were studied. Sulfatides in young and cerebrosides in adults were found to be increased in brains from crinkled mice when compared to their noncrinkled controls. Cholesterol esters, not present at all in the controls, were found in all crinkled brains analyzed. Histologic examination of brain showed abnormalities in myelin structures of varying degrees of severity in all brains from crinkled mice. The observation of cholesterol esters in the brains of crinkled mutants supports the view that the myelin disruption found in these mice is secondary to axonal degeneration.
|Original language||English (US)|
|Number of pages||5|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - 1977|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)