Lipectomy influences white adipose tissue lipoprotein lipase activity and plasma triglyceride levels in ground squirrels

Nancy G. Forger, John Dark, Judith S. Stern, George N. Wade, Irving Zucker

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Golden-mantled ground squirrels undergo marked fattening and fat depletion during the prehibernatory and hibernatory phases, respectively, of their annual body weight cycle. Fat regulation was studied by surgical removal (lipectomy) of most of the inguinal-subcutaneous, retroperitoneal, and parametrial fat depots from female squirrels during the weight-gain phase of the annual cycle. Seven weeks after surgery, body weights of lipectomized (Lipx) and Sham-Lipx squirrels were equivalent, although white adipose tissue was not completely recovered in Lipx animals. Lipoprotein lipase (LPL) activity was markedly elevated in subcutaneous adipose tissue of Lipx squirrels, but not in other depots. Plasma triglyceride (TG) levels also were higher in Lipx squirrels 7 weeks after surgery. Changes in LPL activity and plasma TG may contribute to body mass and lipid restoration following lipectomy.

Original languageEnglish (US)
Pages (from-to)782-786
Number of pages5
JournalMetabolism
Volume37
Issue number8
DOIs
StatePublished - 1988

Fingerprint

Lipectomy
Sciuridae
White Adipose Tissue
Lipoprotein Lipase
Triglycerides
Fats
Body Weight
Intra-Abdominal Fat
Groin
Subcutaneous Fat
Weight Gain
Lipids

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Lipectomy influences white adipose tissue lipoprotein lipase activity and plasma triglyceride levels in ground squirrels. / Forger, Nancy G.; Dark, John; Stern, Judith S.; Wade, George N.; Zucker, Irving.

In: Metabolism, Vol. 37, No. 8, 1988, p. 782-786.

Research output: Contribution to journalArticle

Forger, Nancy G. ; Dark, John ; Stern, Judith S. ; Wade, George N. ; Zucker, Irving. / Lipectomy influences white adipose tissue lipoprotein lipase activity and plasma triglyceride levels in ground squirrels. In: Metabolism. 1988 ; Vol. 37, No. 8. pp. 782-786.
@article{6aaa4414871c4a4bb920e1aded957a4e,
title = "Lipectomy influences white adipose tissue lipoprotein lipase activity and plasma triglyceride levels in ground squirrels",
abstract = "Golden-mantled ground squirrels undergo marked fattening and fat depletion during the prehibernatory and hibernatory phases, respectively, of their annual body weight cycle. Fat regulation was studied by surgical removal (lipectomy) of most of the inguinal-subcutaneous, retroperitoneal, and parametrial fat depots from female squirrels during the weight-gain phase of the annual cycle. Seven weeks after surgery, body weights of lipectomized (Lipx) and Sham-Lipx squirrels were equivalent, although white adipose tissue was not completely recovered in Lipx animals. Lipoprotein lipase (LPL) activity was markedly elevated in subcutaneous adipose tissue of Lipx squirrels, but not in other depots. Plasma triglyceride (TG) levels also were higher in Lipx squirrels 7 weeks after surgery. Changes in LPL activity and plasma TG may contribute to body mass and lipid restoration following lipectomy.",
author = "Forger, {Nancy G.} and John Dark and Stern, {Judith S.} and Wade, {George N.} and Irving Zucker",
year = "1988",
doi = "10.1016/0026-0495(88)90015-7",
language = "English (US)",
volume = "37",
pages = "782--786",
journal = "Metabolism: Clinical and Experimental",
issn = "0026-0495",
publisher = "W.B. Saunders Ltd",
number = "8",

}

TY - JOUR

T1 - Lipectomy influences white adipose tissue lipoprotein lipase activity and plasma triglyceride levels in ground squirrels

AU - Forger, Nancy G.

AU - Dark, John

AU - Stern, Judith S.

AU - Wade, George N.

AU - Zucker, Irving

PY - 1988

Y1 - 1988

N2 - Golden-mantled ground squirrels undergo marked fattening and fat depletion during the prehibernatory and hibernatory phases, respectively, of their annual body weight cycle. Fat regulation was studied by surgical removal (lipectomy) of most of the inguinal-subcutaneous, retroperitoneal, and parametrial fat depots from female squirrels during the weight-gain phase of the annual cycle. Seven weeks after surgery, body weights of lipectomized (Lipx) and Sham-Lipx squirrels were equivalent, although white adipose tissue was not completely recovered in Lipx animals. Lipoprotein lipase (LPL) activity was markedly elevated in subcutaneous adipose tissue of Lipx squirrels, but not in other depots. Plasma triglyceride (TG) levels also were higher in Lipx squirrels 7 weeks after surgery. Changes in LPL activity and plasma TG may contribute to body mass and lipid restoration following lipectomy.

AB - Golden-mantled ground squirrels undergo marked fattening and fat depletion during the prehibernatory and hibernatory phases, respectively, of their annual body weight cycle. Fat regulation was studied by surgical removal (lipectomy) of most of the inguinal-subcutaneous, retroperitoneal, and parametrial fat depots from female squirrels during the weight-gain phase of the annual cycle. Seven weeks after surgery, body weights of lipectomized (Lipx) and Sham-Lipx squirrels were equivalent, although white adipose tissue was not completely recovered in Lipx animals. Lipoprotein lipase (LPL) activity was markedly elevated in subcutaneous adipose tissue of Lipx squirrels, but not in other depots. Plasma triglyceride (TG) levels also were higher in Lipx squirrels 7 weeks after surgery. Changes in LPL activity and plasma TG may contribute to body mass and lipid restoration following lipectomy.

UR - http://www.scopus.com/inward/record.url?scp=0023789444&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023789444&partnerID=8YFLogxK

U2 - 10.1016/0026-0495(88)90015-7

DO - 10.1016/0026-0495(88)90015-7

M3 - Article

VL - 37

SP - 782

EP - 786

JO - Metabolism: Clinical and Experimental

JF - Metabolism: Clinical and Experimental

SN - 0026-0495

IS - 8

ER -