Abstract
Golden-mantled ground squirrels undergo marked fattening and fat depletion during the prehibernatory and hibernatory phases, respectively, of their annual body weight cycle. Fat regulation was studied by surgical removal (lipectomy) of most of the inguinal-subcutaneous, retroperitoneal, and parametrial fat depots from female squirrels during the weight-gain phase of the annual cycle. Seven weeks after surgery, body weights of lipectomized (Lipx) and Sham-Lipx squirrels were equivalent, although white adipose tissue was not completely recovered in Lipx animals. Lipoprotein lipase (LPL) activity was markedly elevated in subcutaneous adipose tissue of Lipx squirrels, but not in other depots. Plasma triglyceride (TG) levels also were higher in Lipx squirrels 7 weeks after surgery. Changes in LPL activity and plasma TG may contribute to body mass and lipid restoration following lipectomy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 782-786 |
| Number of pages | 5 |
| Journal | Metabolism |
| Volume | 37 |
| Issue number | 8 |
| DOIs | |
| State | Published - 1988 |
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ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Lipectomy influences white adipose tissue lipoprotein lipase activity and plasma triglyceride levels in ground squirrels. / Forger, Nancy G.; Dark, John; Stern, Judith S.; Wade, George N.; Zucker, Irving.
In: Metabolism, Vol. 37, No. 8, 1988, p. 782-786.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lipectomy influences white adipose tissue lipoprotein lipase activity and plasma triglyceride levels in ground squirrels
AU - Forger, Nancy G.
AU - Dark, John
AU - Stern, Judith S.
AU - Wade, George N.
AU - Zucker, Irving
PY - 1988
Y1 - 1988
N2 - Golden-mantled ground squirrels undergo marked fattening and fat depletion during the prehibernatory and hibernatory phases, respectively, of their annual body weight cycle. Fat regulation was studied by surgical removal (lipectomy) of most of the inguinal-subcutaneous, retroperitoneal, and parametrial fat depots from female squirrels during the weight-gain phase of the annual cycle. Seven weeks after surgery, body weights of lipectomized (Lipx) and Sham-Lipx squirrels were equivalent, although white adipose tissue was not completely recovered in Lipx animals. Lipoprotein lipase (LPL) activity was markedly elevated in subcutaneous adipose tissue of Lipx squirrels, but not in other depots. Plasma triglyceride (TG) levels also were higher in Lipx squirrels 7 weeks after surgery. Changes in LPL activity and plasma TG may contribute to body mass and lipid restoration following lipectomy.
AB - Golden-mantled ground squirrels undergo marked fattening and fat depletion during the prehibernatory and hibernatory phases, respectively, of their annual body weight cycle. Fat regulation was studied by surgical removal (lipectomy) of most of the inguinal-subcutaneous, retroperitoneal, and parametrial fat depots from female squirrels during the weight-gain phase of the annual cycle. Seven weeks after surgery, body weights of lipectomized (Lipx) and Sham-Lipx squirrels were equivalent, although white adipose tissue was not completely recovered in Lipx animals. Lipoprotein lipase (LPL) activity was markedly elevated in subcutaneous adipose tissue of Lipx squirrels, but not in other depots. Plasma triglyceride (TG) levels also were higher in Lipx squirrels 7 weeks after surgery. Changes in LPL activity and plasma TG may contribute to body mass and lipid restoration following lipectomy.
UR - http://www.scopus.com/inward/record.url?scp=0023789444&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023789444&partnerID=8YFLogxK
U2 - 10.1016/0026-0495(88)90015-7
DO - 10.1016/0026-0495(88)90015-7
M3 - Article
VL - 37
SP - 782
EP - 786
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
SN - 0026-0495
IS - 8
ER -