Abstract
The immunomodulatory potential of a diet enriched with n-3 polyunsaturated fatty acids was analysed in naive mice with experimental antiphospholipid syndrome (APS) induced by active immunization with H-3, a human anti-beta-2-glycoprotein-I (anti-βGPI) monoclonal antibody (mAb). Fetal loss and other clinical manifestations of APS were prevented in the group of APS mice upon exposure to the enriched n-3 diet compared to the control group. The titers of anti-βGPI were significantly lower (in O.D. at 405 nm, 1.387±0.232 in comparison to non-treated mice 0.637±0.111, P<0.05). The reduced titer of anti-βGPI antibodies in the sera of the treated mice was associated with a reduced number of anti-βGPI forming cells in cultured splenocytes (84±14, antibody-forming cells (AFC)/105 cells in comparison to 37±4 AFC/105 cells (P<0.02). In addition to the suppression of the humoral response in mice with experimental APS fed with linseed oil, we also observed an inhibitory effect on the cellular response. The T-cell response to anti-βGPI was lower in comparison to mice immunized with H-3 anti-βGPI mAB, which were kept on a normal diet. These results indicate that polyunsaturated fatty acids may improve clinical and laboratory parameters of APS. The beneficial effects of diets enriched with n-3 should be further examined as a potential mode of therapy for patients with APS. (C) 2000 Academic Press.
Original language | English (US) |
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Pages (from-to) | 381-385 |
Number of pages | 5 |
Journal | Journal of Autoimmunity |
Volume | 15 |
Issue number | 3 |
DOIs | |
State | Published - 2000 |
Keywords
- Anti-beta-2-glycoprotein-I antibodies
- Antiphospholipid syndrome
- Autoantibodies
- Autoimmune diseases
- Nutrition
- Polyunsaturated fatty acids
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy