Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission

Marie Hennebelle; Zhichao Zhang; Adam H. Metherel; Alex P. Kitson; Yurika Otoki; Christine E. Richardson; Jun Yang; Kin Sing Stephen Lee; Bruce D. Hammock; Liang Zhang; Richard P. Bazinet; Ameer Y. Taha

doi:10.1038/s41598-017-02914-7

Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission

Marie Hennebelle, Zhichao Zhang, Adam H. Metherel, Alex P. Kitson, Yurika Otoki, Christine E. Richardson, Jun Yang, Kin Sing Stephen Lee, Bruce D. Hammock, Liang Zhang, Richard P. Bazinet, Ameer Y. Taha

Entomology

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Abstract

Linoleic acid (LA; 18:2 n-6), the most abundant polyunsaturated fatty acid in the US diet, is a precursor to oxidized metabolites that have unknown roles in the brain. Here, we show that oxidized LA-derived metabolites accumulate in several rat brain regions during CO₂-induced ischemia and that LA-derived 13-hydroxyoctadecadienoic acid, but not LA, increase somatic paired-pulse facilitation in rat hippocampus by 80%, suggesting bioactivity. This study provides new evidence that LA participates in the response to ischemia-induced brain injury through oxidized metabolites that regulate neurotransmission. Targeting this pathway may be therapeutically relevant for ischemia-related conditions such as stroke.

Original language	English (US)
Article number	4342
Journal	Scientific Reports
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/s41598-017-02914-7
State	Published - Dec 1 2017

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Hennebelle, M., Zhang, Z., Metherel, A. H., Kitson, A. P., Otoki, Y., Richardson, C. E., Yang, J., Lee, K. S. S., Hammock, B. D., Zhang, L., Bazinet, R. P., & Taha, A. Y. (2017). Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission. Scientific Reports, 7(1), [4342]. https://doi.org/10.1038/s41598-017-02914-7

Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission. / Hennebelle, Marie; Zhang, Zhichao; Metherel, Adam H.; Kitson, Alex P.; Otoki, Yurika; Richardson, Christine E.; Yang, Jun; Lee, Kin Sing Stephen; Hammock, Bruce D.; Zhang, Liang; Bazinet, Richard P.; Taha, Ameer Y.

In: Scientific Reports, Vol. 7, No. 1, 4342, 01.12.2017.

Research output: Contribution to journal › Article › peer-review

Hennebelle, Marie ; Zhang, Zhichao ; Metherel, Adam H. ; Kitson, Alex P. ; Otoki, Yurika ; Richardson, Christine E. ; Yang, Jun ; Lee, Kin Sing Stephen ; Hammock, Bruce D. ; Zhang, Liang ; Bazinet, Richard P. ; Taha, Ameer Y. / Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission. In: Scientific Reports. 2017 ; Vol. 7, No. 1.

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abstract = "Linoleic acid (LA; 18:2 n-6), the most abundant polyunsaturated fatty acid in the US diet, is a precursor to oxidized metabolites that have unknown roles in the brain. Here, we show that oxidized LA-derived metabolites accumulate in several rat brain regions during CO2-induced ischemia and that LA-derived 13-hydroxyoctadecadienoic acid, but not LA, increase somatic paired-pulse facilitation in rat hippocampus by 80%, suggesting bioactivity. This study provides new evidence that LA participates in the response to ischemia-induced brain injury through oxidized metabolites that regulate neurotransmission. Targeting this pathway may be therapeutically relevant for ischemia-related conditions such as stroke.",

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