Abstract
Linoleic acid (LA; 18:2 n-6), the most abundant polyunsaturated fatty acid in the US diet, is a precursor to oxidized metabolites that have unknown roles in the brain. Here, we show that oxidized LA-derived metabolites accumulate in several rat brain regions during CO2-induced ischemia and that LA-derived 13-hydroxyoctadecadienoic acid, but not LA, increase somatic paired-pulse facilitation in rat hippocampus by 80%, suggesting bioactivity. This study provides new evidence that LA participates in the response to ischemia-induced brain injury through oxidized metabolites that regulate neurotransmission. Targeting this pathway may be therapeutically relevant for ischemia-related conditions such as stroke.
| Original language | English (US) |
|---|---|
| Article number | 4342 |
| Journal | Scientific Reports |
| Volume | 7 |
| Issue number | 1 |
| DOIs | |
| State | Published - Dec 1 2017 |
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Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission. / Hennebelle, Marie; Zhang, Zhichao; Metherel, Adam H.; Kitson, Alex P.; Otoki, Yurika; Richardson, Christine E.; Yang, Jun; Lee, Kin Sing Stephen; Hammock, Bruce D.; Zhang, Liang; Bazinet, Richard P.; Taha, Ameer Y.
In: Scientific Reports, Vol. 7, No. 1, 4342, 01.12.2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission
AU - Hennebelle, Marie
AU - Zhang, Zhichao
AU - Metherel, Adam H.
AU - Kitson, Alex P.
AU - Otoki, Yurika
AU - Richardson, Christine E.
AU - Yang, Jun
AU - Lee, Kin Sing Stephen
AU - Hammock, Bruce D.
AU - Zhang, Liang
AU - Bazinet, Richard P.
AU - Taha, Ameer Y.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Linoleic acid (LA; 18:2 n-6), the most abundant polyunsaturated fatty acid in the US diet, is a precursor to oxidized metabolites that have unknown roles in the brain. Here, we show that oxidized LA-derived metabolites accumulate in several rat brain regions during CO2-induced ischemia and that LA-derived 13-hydroxyoctadecadienoic acid, but not LA, increase somatic paired-pulse facilitation in rat hippocampus by 80%, suggesting bioactivity. This study provides new evidence that LA participates in the response to ischemia-induced brain injury through oxidized metabolites that regulate neurotransmission. Targeting this pathway may be therapeutically relevant for ischemia-related conditions such as stroke.
AB - Linoleic acid (LA; 18:2 n-6), the most abundant polyunsaturated fatty acid in the US diet, is a precursor to oxidized metabolites that have unknown roles in the brain. Here, we show that oxidized LA-derived metabolites accumulate in several rat brain regions during CO2-induced ischemia and that LA-derived 13-hydroxyoctadecadienoic acid, but not LA, increase somatic paired-pulse facilitation in rat hippocampus by 80%, suggesting bioactivity. This study provides new evidence that LA participates in the response to ischemia-induced brain injury through oxidized metabolites that regulate neurotransmission. Targeting this pathway may be therapeutically relevant for ischemia-related conditions such as stroke.
UR - http://www.scopus.com/inward/record.url?scp=85021634988&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85021634988&partnerID=8YFLogxK
U2 - 10.1038/s41598-017-02914-7
DO - 10.1038/s41598-017-02914-7
M3 - Article
AN - SCOPUS:85021634988
VL - 7
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 4342
ER -