Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission

Marie Hennebelle; Zhichao Zhang; Adam H. Metherel; Alex P. Kitson; Yurika Otoki; Christine E. Richardson; Jun Yang; Kin Sing Stephen Lee; Bruce D. Hammock; Liang Zhang; Richard P. Bazinet; Ameer Y. Taha

doi:10.1038/s41598-017-02914-7

Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission

Marie Hennebelle, Zhichao Zhang, Adam H. Metherel, Alex P. Kitson, Yurika Otoki, Christine E. Richardson, Jun Yang, Kin Sing Stephen Lee, Bruce D. Hammock, Liang Zhang, Richard P. Bazinet, Ameer Y. Taha

Entomology

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Linoleic acid (LA; 18:2 n-6), the most abundant polyunsaturated fatty acid in the US diet, is a precursor to oxidized metabolites that have unknown roles in the brain. Here, we show that oxidized LA-derived metabolites accumulate in several rat brain regions during CO₂-induced ischemia and that LA-derived 13-hydroxyoctadecadienoic acid, but not LA, increase somatic paired-pulse facilitation in rat hippocampus by 80%, suggesting bioactivity. This study provides new evidence that LA participates in the response to ischemia-induced brain injury through oxidized metabolites that regulate neurotransmission. Targeting this pathway may be therapeutically relevant for ischemia-related conditions such as stroke.

Original language	English (US)
Article number	4342
Journal	Scientific Reports
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/s41598-017-02914-7
State	Published - Dec 1 2017

ASJC Scopus subject areas

General

Access to Document

10.1038/s41598-017-02914-7

Cite this

Hennebelle, M., Zhang, Z., Metherel, A. H., Kitson, A. P., Otoki, Y., Richardson, C. E., Yang, J., Lee, K. S. S., Hammock, B. D., Zhang, L., Bazinet, R. P., & Taha, A. Y. (2017). Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission. Scientific Reports, 7(1), [4342]. https://doi.org/10.1038/s41598-017-02914-7

Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission. / Hennebelle, Marie; Zhang, Zhichao; Metherel, Adam H.; Kitson, Alex P.; Otoki, Yurika; Richardson, Christine E.; Yang, Jun; Lee, Kin Sing Stephen; Hammock, Bruce D.; Zhang, Liang; Bazinet, Richard P.; Taha, Ameer Y.

In: Scientific Reports, Vol. 7, No. 1, 4342, 01.12.2017.

Research output: Contribution to journal › Article › peer-review

Hennebelle, Marie ; Zhang, Zhichao ; Metherel, Adam H. ; Kitson, Alex P. ; Otoki, Yurika ; Richardson, Christine E. ; Yang, Jun ; Lee, Kin Sing Stephen ; Hammock, Bruce D. ; Zhang, Liang ; Bazinet, Richard P. ; Taha, Ameer Y. / Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission. In: Scientific Reports. 2017 ; Vol. 7, No. 1.

@article{6e0476ab0c6f47a4b1c02ca031cf0e1e,

title = "Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission",

abstract = "Linoleic acid (LA; 18:2 n-6), the most abundant polyunsaturated fatty acid in the US diet, is a precursor to oxidized metabolites that have unknown roles in the brain. Here, we show that oxidized LA-derived metabolites accumulate in several rat brain regions during CO2-induced ischemia and that LA-derived 13-hydroxyoctadecadienoic acid, but not LA, increase somatic paired-pulse facilitation in rat hippocampus by 80%, suggesting bioactivity. This study provides new evidence that LA participates in the response to ischemia-induced brain injury through oxidized metabolites that regulate neurotransmission. Targeting this pathway may be therapeutically relevant for ischemia-related conditions such as stroke.",

author = "Marie Hennebelle and Zhichao Zhang and Metherel, {Adam H.} and Kitson, {Alex P.} and Yurika Otoki and Richardson, {Christine E.} and Jun Yang and Lee, {Kin Sing Stephen} and Hammock, {Bruce D.} and Liang Zhang and Bazinet, {Richard P.} and Taha, {Ameer Y.}",

year = "2017",

month = dec,

day = "1",

doi = "10.1038/s41598-017-02914-7",

language = "English (US)",

volume = "7",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission

AU - Hennebelle, Marie

AU - Zhang, Zhichao

AU - Metherel, Adam H.

AU - Kitson, Alex P.

AU - Otoki, Yurika

AU - Richardson, Christine E.

AU - Yang, Jun

AU - Lee, Kin Sing Stephen

AU - Hammock, Bruce D.

AU - Zhang, Liang

AU - Bazinet, Richard P.

AU - Taha, Ameer Y.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Linoleic acid (LA; 18:2 n-6), the most abundant polyunsaturated fatty acid in the US diet, is a precursor to oxidized metabolites that have unknown roles in the brain. Here, we show that oxidized LA-derived metabolites accumulate in several rat brain regions during CO2-induced ischemia and that LA-derived 13-hydroxyoctadecadienoic acid, but not LA, increase somatic paired-pulse facilitation in rat hippocampus by 80%, suggesting bioactivity. This study provides new evidence that LA participates in the response to ischemia-induced brain injury through oxidized metabolites that regulate neurotransmission. Targeting this pathway may be therapeutically relevant for ischemia-related conditions such as stroke.

AB - Linoleic acid (LA; 18:2 n-6), the most abundant polyunsaturated fatty acid in the US diet, is a precursor to oxidized metabolites that have unknown roles in the brain. Here, we show that oxidized LA-derived metabolites accumulate in several rat brain regions during CO2-induced ischemia and that LA-derived 13-hydroxyoctadecadienoic acid, but not LA, increase somatic paired-pulse facilitation in rat hippocampus by 80%, suggesting bioactivity. This study provides new evidence that LA participates in the response to ischemia-induced brain injury through oxidized metabolites that regulate neurotransmission. Targeting this pathway may be therapeutically relevant for ischemia-related conditions such as stroke.

UR - http://www.scopus.com/inward/record.url?scp=85021634988&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021634988&partnerID=8YFLogxK

U2 - 10.1038/s41598-017-02914-7

DO - 10.1038/s41598-017-02914-7

M3 - Article

AN - SCOPUS:85021634988

VL - 7

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 4342

ER -

Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this