Linking radiometals to proteins with bifunctional chelating agents

C. F. Meares; D. A. Goodwin

doi:10.1007/BF01040501

Linking radiometals to proteins with bifunctional chelating agents

C. F. Meares, D. A. Goodwin

Chemistry

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Bifunctional chelating agents contain a metal chelating group and a second functional group that is usually chemically reactive in nature. They allow stable attachment of radioactive metal ions to proteins and other biological molecules, for use as radiopharmaceuticals and in other applications. Their chemical synthesis, attachment to proteins, and reaction with metals are briefly reviewed. Properties in vivo of chelate-tagged transferrin, chelate-tagged antibody to the transferrin cell-surface receptor, and¹¹¹indium-transferrin are compared.

Original language	English (US)
Pages (from-to)	215-228
Number of pages	14
Journal	Journal of Protein Chemistry
Volume	3
Issue number	2
DOIs	https://doi.org/10.1007/BF01040501
State	Published - Apr 1984

Keywords

antibodies
chelates
chemical modification
metals

ASJC Scopus subject areas

Biochemistry

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10.1007/BF01040501

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abstract = "Bifunctional chelating agents contain a metal chelating group and a second functional group that is usually chemically reactive in nature. They allow stable attachment of radioactive metal ions to proteins and other biological molecules, for use as radiopharmaceuticals and in other applications. Their chemical synthesis, attachment to proteins, and reaction with metals are briefly reviewed. Properties in vivo of chelate-tagged transferrin, chelate-tagged antibody to the transferrin cell-surface receptor, and111indium-transferrin are compared.",

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author = "Meares, {C. F.} and Goodwin, {D. A.}",

year = "1984",

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AU - Meares, C. F.

AU - Goodwin, D. A.

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AB - Bifunctional chelating agents contain a metal chelating group and a second functional group that is usually chemically reactive in nature. They allow stable attachment of radioactive metal ions to proteins and other biological molecules, for use as radiopharmaceuticals and in other applications. Their chemical synthesis, attachment to proteins, and reaction with metals are briefly reviewed. Properties in vivo of chelate-tagged transferrin, chelate-tagged antibody to the transferrin cell-surface receptor, and111indium-transferrin are compared.

KW - antibodies

KW - chelates

KW - chemical modification

KW - metals

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Linking radiometals to proteins with bifunctional chelating agents

Abstract

Keywords

ASJC Scopus subject areas

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