Bifunctional chelating agents contain a metal chelating group and a second functional group that is usually chemically reactive in nature. They allow stable attachment of radioactive metal ions to proteins and other biological molecules, for use as radiopharmaceuticals and in other applications. Their chemical synthesis, attachment to proteins, and reaction with metals are briefly reviewed. Properties in vivo of chelate-tagged transferrin, chelate-tagged antibody to the transferrin cell-surface receptor, and111indium-transferrin are compared.
- chemical modification
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