Linking radiometals to proteins with bifunctional chelating agents

C. F. Meares, D. A. Goodwin

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Bifunctional chelating agents contain a metal chelating group and a second functional group that is usually chemically reactive in nature. They allow stable attachment of radioactive metal ions to proteins and other biological molecules, for use as radiopharmaceuticals and in other applications. Their chemical synthesis, attachment to proteins, and reaction with metals are briefly reviewed. Properties in vivo of chelate-tagged transferrin, chelate-tagged antibody to the transferrin cell-surface receptor, and111indium-transferrin are compared.

Original languageEnglish (US)
Pages (from-to)215-228
Number of pages14
JournalJournal of Protein Chemistry
Issue number2
StatePublished - Apr 1984


  • antibodies
  • chelates
  • chemical modification
  • metals

ASJC Scopus subject areas

  • Biochemistry


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