Abstract
Bifunctional chelating agents contain a metal chelating group and a second functional group that is usually chemically reactive in nature. They allow stable attachment of radioactive metal ions to proteins and other biological molecules, for use as radiopharmaceuticals and in other applications. Their chemical synthesis, attachment to proteins, and reaction with metals are briefly reviewed. Properties in vivo of chelate-tagged transferrin, chelate-tagged antibody to the transferrin cell-surface receptor, and111indium-transferrin are compared.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 215-228 |
| Number of pages | 14 |
| Journal | Journal of Protein Chemistry |
| Volume | 3 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 1984 |
Keywords
- antibodies
- chelates
- chemical modification
- metals
ASJC Scopus subject areas
- Biochemistry
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Meares, C. F., & Goodwin, D. A. (1984). Linking radiometals to proteins with bifunctional chelating agents. Journal of Protein Chemistry, 3(2), 215-228. https://doi.org/10.1007/BF01040501