Linkage of the grey coat colour locus to microsatellites on horse chromosome 25

M. M. Locke, Cecilia Penedo, S. J. Bricker, L. V. Millon, J. D. Murray

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The progressive loss of colour in the hair of grey horses is controlled by a dominantly inherited allele at the Grey locus (GG). In this study, two paternal Quarter Horse (QH) families segregating for the GG allele were genotyped with a set of 101 microsatellite markers spanning the 31 autosomes and the X chromosome. This genome scan demonstrated linkage of Grey to COR018 (RF = 0.02, LOD = 12.04) on horse chromosome 25 (ECA25). Further chromosome-specific analysis of seven total QH families confirmed the linkage of Grey to a group of ECA25 markers and the map order of NVHEQ43-(0.24)-UCDEQ405-(0.09)-COR080-(0.05)-GREY-(0.14)-UCDEQ464 was produced. Although G was found to be linked to TXN and COR018 in the chromosome-specific analysis, the data were not sufficiently informative to place either marker on our ECA25 map with significant LODs. Our results excluded the equine tyrosinase related protein 1 (TYRP1) and melanocyte protein 17 (Pmel 17) genes as possible candidates for the grey phenotype in horses.

Original languageEnglish (US)
Pages (from-to)329-337
Number of pages9
JournalAnimal Genetics
Volume33
Issue number5
DOIs
StatePublished - Oct 1 2002

Fingerprint

Microsatellite Repeats
Horses
linkage (genetics)
Color
Chromosomes
microsatellite repeats
chromosomes
horses
Quarter Horse
loci
color
alleles
melanocytes
autosomes
X chromosome
Alleles
Hair Color
hairs
data analysis
proteins

Keywords

  • Coat colour
  • Gene mapping
  • Grey
  • Horse genetics
  • Microsatellite

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Genetics

Cite this

Linkage of the grey coat colour locus to microsatellites on horse chromosome 25. / Locke, M. M.; Penedo, Cecilia; Bricker, S. J.; Millon, L. V.; Murray, J. D.

In: Animal Genetics, Vol. 33, No. 5, 01.10.2002, p. 329-337.

Research output: Contribution to journalArticle

Locke, M. M. ; Penedo, Cecilia ; Bricker, S. J. ; Millon, L. V. ; Murray, J. D. / Linkage of the grey coat colour locus to microsatellites on horse chromosome 25. In: Animal Genetics. 2002 ; Vol. 33, No. 5. pp. 329-337.
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