Linkage of the grey coat colour locus to microsatellites on horse chromosome 25

M. M. Locke; Cecilia Penedo; S. J. Bricker; L. V. Millon; J. D. Murray

doi:10.1046/j.1365-2052.2002.00885.x

Linkage of the grey coat colour locus to microsatellites on horse chromosome 25

M. M. Locke, Cecilia Penedo, S. J. Bricker, L. V. Millon, J. D. Murray

School of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

The progressive loss of colour in the hair of grey horses is controlled by a dominantly inherited allele at the Grey locus (G^G). In this study, two paternal Quarter Horse (QH) families segregating for the G^G allele were genotyped with a set of 101 microsatellite markers spanning the 31 autosomes and the X chromosome. This genome scan demonstrated linkage of Grey to COR018 (RF = 0.02, LOD = 12.04) on horse chromosome 25 (ECA25). Further chromosome-specific analysis of seven total QH families confirmed the linkage of Grey to a group of ECA25 markers and the map order of NVHEQ43-(0.24)-UCDEQ405-(0.09)-COR080-(0.05)-GREY-(0.14)-UCDEQ464 was produced. Although G was found to be linked to TXN and COR018 in the chromosome-specific analysis, the data were not sufficiently informative to place either marker on our ECA25 map with significant LODs. Our results excluded the equine tyrosinase related protein 1 (TYRP1) and melanocyte protein 17 (Pmel 17) genes as possible candidates for the grey phenotype in horses.

Original language	English (US)
Pages (from-to)	329-337
Number of pages	9
Journal	Animal Genetics
Volume	33
Issue number	5
DOIs	https://doi.org/10.1046/j.1365-2052.2002.00885.x
State	Published - Oct 1 2002

Keywords

Coat colour
Gene mapping
Grey
Horse genetics
Microsatellite

ASJC Scopus subject areas

Animal Science and Zoology
Genetics

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title = "Linkage of the grey coat colour locus to microsatellites on horse chromosome 25",

abstract = "The progressive loss of colour in the hair of grey horses is controlled by a dominantly inherited allele at the Grey locus (GG). In this study, two paternal Quarter Horse (QH) families segregating for the GG allele were genotyped with a set of 101 microsatellite markers spanning the 31 autosomes and the X chromosome. This genome scan demonstrated linkage of Grey to COR018 (RF = 0.02, LOD = 12.04) on horse chromosome 25 (ECA25). Further chromosome-specific analysis of seven total QH families confirmed the linkage of Grey to a group of ECA25 markers and the map order of NVHEQ43-(0.24)-UCDEQ405-(0.09)-COR080-(0.05)-GREY-(0.14)-UCDEQ464 was produced. Although G was found to be linked to TXN and COR018 in the chromosome-specific analysis, the data were not sufficiently informative to place either marker on our ECA25 map with significant LODs. Our results excluded the equine tyrosinase related protein 1 (TYRP1) and melanocyte protein 17 (Pmel 17) genes as possible candidates for the grey phenotype in horses.",

keywords = "Coat colour, Gene mapping, Grey, Horse genetics, Microsatellite",

author = "Locke, {M. M.} and Cecilia Penedo and Bricker, {S. J.} and Millon, {L. V.} and Murray, {J. D.}",

year = "2002",

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doi = "10.1046/j.1365-2052.2002.00885.x",

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AU - Locke, M. M.

AU - Penedo, Cecilia

AU - Bricker, S. J.

AU - Millon, L. V.

AU - Murray, J. D.

PY - 2002/10/1

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N2 - The progressive loss of colour in the hair of grey horses is controlled by a dominantly inherited allele at the Grey locus (GG). In this study, two paternal Quarter Horse (QH) families segregating for the GG allele were genotyped with a set of 101 microsatellite markers spanning the 31 autosomes and the X chromosome. This genome scan demonstrated linkage of Grey to COR018 (RF = 0.02, LOD = 12.04) on horse chromosome 25 (ECA25). Further chromosome-specific analysis of seven total QH families confirmed the linkage of Grey to a group of ECA25 markers and the map order of NVHEQ43-(0.24)-UCDEQ405-(0.09)-COR080-(0.05)-GREY-(0.14)-UCDEQ464 was produced. Although G was found to be linked to TXN and COR018 in the chromosome-specific analysis, the data were not sufficiently informative to place either marker on our ECA25 map with significant LODs. Our results excluded the equine tyrosinase related protein 1 (TYRP1) and melanocyte protein 17 (Pmel 17) genes as possible candidates for the grey phenotype in horses.

AB - The progressive loss of colour in the hair of grey horses is controlled by a dominantly inherited allele at the Grey locus (GG). In this study, two paternal Quarter Horse (QH) families segregating for the GG allele were genotyped with a set of 101 microsatellite markers spanning the 31 autosomes and the X chromosome. This genome scan demonstrated linkage of Grey to COR018 (RF = 0.02, LOD = 12.04) on horse chromosome 25 (ECA25). Further chromosome-specific analysis of seven total QH families confirmed the linkage of Grey to a group of ECA25 markers and the map order of NVHEQ43-(0.24)-UCDEQ405-(0.09)-COR080-(0.05)-GREY-(0.14)-UCDEQ464 was produced. Although G was found to be linked to TXN and COR018 in the chromosome-specific analysis, the data were not sufficiently informative to place either marker on our ECA25 map with significant LODs. Our results excluded the equine tyrosinase related protein 1 (TYRP1) and melanocyte protein 17 (Pmel 17) genes as possible candidates for the grey phenotype in horses.

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KW - Gene mapping

KW - Grey

KW - Horse genetics

KW - Microsatellite

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Linkage of the grey coat colour locus to microsatellites on horse chromosome 25

Abstract

Keywords

ASJC Scopus subject areas

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