Abstract
The progressive loss of colour in the hair of grey horses is controlled by a dominantly inherited allele at the Grey locus (GG). In this study, two paternal Quarter Horse (QH) families segregating for the GG allele were genotyped with a set of 101 microsatellite markers spanning the 31 autosomes and the X chromosome. This genome scan demonstrated linkage of Grey to COR018 (RF = 0.02, LOD = 12.04) on horse chromosome 25 (ECA25). Further chromosome-specific analysis of seven total QH families confirmed the linkage of Grey to a group of ECA25 markers and the map order of NVHEQ43-(0.24)-UCDEQ405-(0.09)-COR080-(0.05)-GREY-(0.14)-UCDEQ464 was produced. Although G was found to be linked to TXN and COR018 in the chromosome-specific analysis, the data were not sufficiently informative to place either marker on our ECA25 map with significant LODs. Our results excluded the equine tyrosinase related protein 1 (TYRP1) and melanocyte protein 17 (Pmel 17) genes as possible candidates for the grey phenotype in horses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 329-337 |
| Number of pages | 9 |
| Journal | Animal Genetics |
| Volume | 33 |
| Issue number | 5 |
| DOIs | |
| State | Published - Oct 1 2002 |
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Keywords
- Coat colour
- Gene mapping
- Grey
- Horse genetics
- Microsatellite
ASJC Scopus subject areas
- Animal Science and Zoology
- Genetics
Cite this
Linkage of the grey coat colour locus to microsatellites on horse chromosome 25. / Locke, M. M.; Penedo, Cecilia; Bricker, S. J.; Millon, L. V.; Murray, J. D.
In: Animal Genetics, Vol. 33, No. 5, 01.10.2002, p. 329-337.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Linkage of the grey coat colour locus to microsatellites on horse chromosome 25
AU - Locke, M. M.
AU - Penedo, Cecilia
AU - Bricker, S. J.
AU - Millon, L. V.
AU - Murray, J. D.
PY - 2002/10/1
Y1 - 2002/10/1
N2 - The progressive loss of colour in the hair of grey horses is controlled by a dominantly inherited allele at the Grey locus (GG). In this study, two paternal Quarter Horse (QH) families segregating for the GG allele were genotyped with a set of 101 microsatellite markers spanning the 31 autosomes and the X chromosome. This genome scan demonstrated linkage of Grey to COR018 (RF = 0.02, LOD = 12.04) on horse chromosome 25 (ECA25). Further chromosome-specific analysis of seven total QH families confirmed the linkage of Grey to a group of ECA25 markers and the map order of NVHEQ43-(0.24)-UCDEQ405-(0.09)-COR080-(0.05)-GREY-(0.14)-UCDEQ464 was produced. Although G was found to be linked to TXN and COR018 in the chromosome-specific analysis, the data were not sufficiently informative to place either marker on our ECA25 map with significant LODs. Our results excluded the equine tyrosinase related protein 1 (TYRP1) and melanocyte protein 17 (Pmel 17) genes as possible candidates for the grey phenotype in horses.
AB - The progressive loss of colour in the hair of grey horses is controlled by a dominantly inherited allele at the Grey locus (GG). In this study, two paternal Quarter Horse (QH) families segregating for the GG allele were genotyped with a set of 101 microsatellite markers spanning the 31 autosomes and the X chromosome. This genome scan demonstrated linkage of Grey to COR018 (RF = 0.02, LOD = 12.04) on horse chromosome 25 (ECA25). Further chromosome-specific analysis of seven total QH families confirmed the linkage of Grey to a group of ECA25 markers and the map order of NVHEQ43-(0.24)-UCDEQ405-(0.09)-COR080-(0.05)-GREY-(0.14)-UCDEQ464 was produced. Although G was found to be linked to TXN and COR018 in the chromosome-specific analysis, the data were not sufficiently informative to place either marker on our ECA25 map with significant LODs. Our results excluded the equine tyrosinase related protein 1 (TYRP1) and melanocyte protein 17 (Pmel 17) genes as possible candidates for the grey phenotype in horses.
KW - Coat colour
KW - Gene mapping
KW - Grey
KW - Horse genetics
KW - Microsatellite
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UR - http://www.scopus.com/inward/citedby.url?scp=0036802655&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2052.2002.00885.x
DO - 10.1046/j.1365-2052.2002.00885.x
M3 - Article
C2 - 12354140
AN - SCOPUS:0036802655
VL - 33
SP - 329
EP - 337
JO - Animal Genetics
JF - Animal Genetics
SN - 0268-9146
IS - 5
ER -