Linkage Map

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Linkage/genetic maps provide a method for examining the relationship between traits and chromosomal location. In human genetic studies, although association tests do not require a linkage map, these maps (i.e., recombinations) are incorporated into imputation algorithms that can be a major adjunct in defining specific sequence variations associated with a trait. For other species, linkage maps can also provide a framework for positional cloning efforts and defining the position of both Mendelian and quantitative trait loci.

Original languageEnglish (US)
Title of host publicationBrenner's Encyclopedia of Genetics
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages255-257
Number of pages3
ISBN (Electronic)9780080961569
ISBN (Print)9780123749840
DOIs
StatePublished - Feb 27 2013

Fingerprint

Genetic Linkage
Quantitative Trait Loci
Medical Genetics
Genetic Recombination
chromosome mapping
Organism Cloning
linkage (genetics)
molecular cloning
quantitative trait loci
Cloning
testing
methodology
sequence diversity

Keywords

  • Centimorgan
  • Chromosomal location
  • Genetic maps
  • Homology relationships
  • Imputation
  • Linkage

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Seldin, M. F. (2013). Linkage Map. In Brenner's Encyclopedia of Genetics: Second Edition (pp. 255-257). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374984-0.00872-X

Linkage Map. / Seldin, Michael F.

Brenner's Encyclopedia of Genetics: Second Edition. Elsevier Inc., 2013. p. 255-257.

Research output: Chapter in Book/Report/Conference proceedingChapter

Seldin, MF 2013, Linkage Map. in Brenner's Encyclopedia of Genetics: Second Edition. Elsevier Inc., pp. 255-257. https://doi.org/10.1016/B978-0-12-374984-0.00872-X
Seldin MF. Linkage Map. In Brenner's Encyclopedia of Genetics: Second Edition. Elsevier Inc. 2013. p. 255-257 https://doi.org/10.1016/B978-0-12-374984-0.00872-X
Seldin, Michael F. / Linkage Map. Brenner's Encyclopedia of Genetics: Second Edition. Elsevier Inc., 2013. pp. 255-257
@inbook{0d93bb1cc0514f45a44bc91c30df2d2d,
title = "Linkage Map",
abstract = "Linkage/genetic maps provide a method for examining the relationship between traits and chromosomal location. In human genetic studies, although association tests do not require a linkage map, these maps (i.e., recombinations) are incorporated into imputation algorithms that can be a major adjunct in defining specific sequence variations associated with a trait. For other species, linkage maps can also provide a framework for positional cloning efforts and defining the position of both Mendelian and quantitative trait loci.",
keywords = "Centimorgan, Chromosomal location, Genetic maps, Homology relationships, Imputation, Linkage",
author = "Seldin, {Michael F}",
year = "2013",
month = "2",
day = "27",
doi = "10.1016/B978-0-12-374984-0.00872-X",
language = "English (US)",
isbn = "9780123749840",
pages = "255--257",
booktitle = "Brenner's Encyclopedia of Genetics",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Linkage Map

AU - Seldin, Michael F

PY - 2013/2/27

Y1 - 2013/2/27

N2 - Linkage/genetic maps provide a method for examining the relationship between traits and chromosomal location. In human genetic studies, although association tests do not require a linkage map, these maps (i.e., recombinations) are incorporated into imputation algorithms that can be a major adjunct in defining specific sequence variations associated with a trait. For other species, linkage maps can also provide a framework for positional cloning efforts and defining the position of both Mendelian and quantitative trait loci.

AB - Linkage/genetic maps provide a method for examining the relationship between traits and chromosomal location. In human genetic studies, although association tests do not require a linkage map, these maps (i.e., recombinations) are incorporated into imputation algorithms that can be a major adjunct in defining specific sequence variations associated with a trait. For other species, linkage maps can also provide a framework for positional cloning efforts and defining the position of both Mendelian and quantitative trait loci.

KW - Centimorgan

KW - Chromosomal location

KW - Genetic maps

KW - Homology relationships

KW - Imputation

KW - Linkage

UR - http://www.scopus.com/inward/record.url?scp=85043283298&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85043283298&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-374984-0.00872-X

DO - 10.1016/B978-0-12-374984-0.00872-X

M3 - Chapter

AN - SCOPUS:85043283298

SN - 9780123749840

SP - 255

EP - 257

BT - Brenner's Encyclopedia of Genetics

PB - Elsevier Inc.

ER -