Linkage analysis of multiple endocrine neoplasia type 1 with INT2 and other markers on chromosome 11

Sherri J. Bale, Allen E. Bale, Karen Stewart, Laura Dachowski, O. W. McBride, Thomas M Glaser, Joseph E. Green, John J. Mulvihill, Maria Luisa Brandi, Kazushige Sakaguchi, Gerald D. Aurbach, Stephen J. Marx

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

We evaluated linkage between the locus for multiple endocrine neoplasia type 1 (MEN1) and several polymorphic DNA markers on chromosome 11 in a single large pedigree. On the basis of the finding of a basic fibroblast growth factor (bFGF)-like substance circulating in plasma of MEN1 patients, we chose a bFGF-related gene known to be localized to 11q13 as one of the markers. This gene locus, INT2, was found to be closely linked to the MEN1 gene. Pairwise and multipoint analyses with INT2 confirm the recent finding by C. Larsson et al. (1988, Nature (London) 332: 85-87) of MEN1 linkage to another marker, skeletal muscle glycogen phosphorylase, at 11q13.

Original languageEnglish (US)
Pages (from-to)320-322
Number of pages3
JournalGenomics
Volume4
Issue number3
DOIs
StatePublished - 1989
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Genetics

Cite this

Bale, S. J., Bale, A. E., Stewart, K., Dachowski, L., McBride, O. W., Glaser, T. M., Green, J. E., Mulvihill, J. J., Brandi, M. L., Sakaguchi, K., Aurbach, G. D., & Marx, S. J. (1989). Linkage analysis of multiple endocrine neoplasia type 1 with INT2 and other markers on chromosome 11. Genomics, 4(3), 320-322. https://doi.org/10.1016/0888-7543(89)90336-4