Lindane does affect the granule cell population of the dentate gyrus. The granule cells become more reactive to perforant path input. An increase in transmitter release at perforant path terminals does not appear to be responsible for this effect. Rather, lindane appears to act directly on the granule cell to increase its excitability or it may act indirectly through other afferents impinging on it. There is no evidence at this locus that lindane antagonizes GABA-mediated inhibition. In intact mammalian subjects the actions of lindane are similar in both neocortex and limbic cortex. Major output neurons demonstrate increased responsiveness to excitatory inputs, but in neither region can depression of inhibition be demonstrated. Further studies are clearly warranted to correlate mechanisms of action suggested by in vitro approaches with the types of changes that can be shown to occur in vivo.
|Original language||English (US)|
|Number of pages||22|
|State||Published - 1985|
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience