Lindane and limbic system excitability

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Lindane does affect the granule cell population of the dentate gyrus. The granule cells become more reactive to perforant path input. An increase in transmitter release at perforant path terminals does not appear to be responsible for this effect. Rather, lindane appears to act directly on the granule cell to increase its excitability or it may act indirectly through other afferents impinging on it. There is no evidence at this locus that lindane antagonizes GABA-mediated inhibition. In intact mammalian subjects the actions of lindane are similar in both neocortex and limbic cortex. Major output neurons demonstrate increased responsiveness to excitatory inputs, but in neither region can depression of inhibition be demonstrated. Further studies are clearly warranted to correlate mechanisms of action suggested by in vitro approaches with the types of changes that can be shown to occur in vivo.

Original languageEnglish (US)
Pages (from-to)193-214
Number of pages22
JournalNeuroToxicology
Volume6
Issue number2
StatePublished - 1985

Fingerprint

Lindane
Limbic System
Perforant Pathway
Neocortex
Dentate Gyrus
gamma-Aminobutyric Acid
Neurons
Transmitters
Cells
Population

ASJC Scopus subject areas

  • Neuroscience(all)
  • Cellular and Molecular Neuroscience
  • Toxicology

Cite this

Lindane and limbic system excitability. / Joy, R. M.; Albertson, Timothy E.

In: NeuroToxicology, Vol. 6, No. 2, 1985, p. 193-214.

Research output: Contribution to journalArticle

Joy, RM & Albertson, TE 1985, 'Lindane and limbic system excitability', NeuroToxicology, vol. 6, no. 2, pp. 193-214.
Joy, R. M. ; Albertson, Timothy E. / Lindane and limbic system excitability. In: NeuroToxicology. 1985 ; Vol. 6, No. 2. pp. 193-214.
@article{b8b47a21b46d4a2e813329f18abd49c5,
title = "Lindane and limbic system excitability",
abstract = "Lindane does affect the granule cell population of the dentate gyrus. The granule cells become more reactive to perforant path input. An increase in transmitter release at perforant path terminals does not appear to be responsible for this effect. Rather, lindane appears to act directly on the granule cell to increase its excitability or it may act indirectly through other afferents impinging on it. There is no evidence at this locus that lindane antagonizes GABA-mediated inhibition. In intact mammalian subjects the actions of lindane are similar in both neocortex and limbic cortex. Major output neurons demonstrate increased responsiveness to excitatory inputs, but in neither region can depression of inhibition be demonstrated. Further studies are clearly warranted to correlate mechanisms of action suggested by in vitro approaches with the types of changes that can be shown to occur in vivo.",
author = "Joy, {R. M.} and Albertson, {Timothy E}",
year = "1985",
language = "English (US)",
volume = "6",
pages = "193--214",
journal = "NeuroToxicology",
issn = "0161-813X",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Lindane and limbic system excitability

AU - Joy, R. M.

AU - Albertson, Timothy E

PY - 1985

Y1 - 1985

N2 - Lindane does affect the granule cell population of the dentate gyrus. The granule cells become more reactive to perforant path input. An increase in transmitter release at perforant path terminals does not appear to be responsible for this effect. Rather, lindane appears to act directly on the granule cell to increase its excitability or it may act indirectly through other afferents impinging on it. There is no evidence at this locus that lindane antagonizes GABA-mediated inhibition. In intact mammalian subjects the actions of lindane are similar in both neocortex and limbic cortex. Major output neurons demonstrate increased responsiveness to excitatory inputs, but in neither region can depression of inhibition be demonstrated. Further studies are clearly warranted to correlate mechanisms of action suggested by in vitro approaches with the types of changes that can be shown to occur in vivo.

AB - Lindane does affect the granule cell population of the dentate gyrus. The granule cells become more reactive to perforant path input. An increase in transmitter release at perforant path terminals does not appear to be responsible for this effect. Rather, lindane appears to act directly on the granule cell to increase its excitability or it may act indirectly through other afferents impinging on it. There is no evidence at this locus that lindane antagonizes GABA-mediated inhibition. In intact mammalian subjects the actions of lindane are similar in both neocortex and limbic cortex. Major output neurons demonstrate increased responsiveness to excitatory inputs, but in neither region can depression of inhibition be demonstrated. Further studies are clearly warranted to correlate mechanisms of action suggested by in vitro approaches with the types of changes that can be shown to occur in vivo.

UR - http://www.scopus.com/inward/record.url?scp=0022263657&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022263657&partnerID=8YFLogxK

M3 - Article

C2 - 2410826

AN - SCOPUS:0022263657

VL - 6

SP - 193

EP - 214

JO - NeuroToxicology

JF - NeuroToxicology

SN - 0161-813X

IS - 2

ER -