Limited fiber type grouping in self-reinnervation cat tibialis anterior muscles

Graciela A. Unguez, Roland R. Roy, Sue Bodine-Fowler, V. Reggie Edgerton

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The percent and distribution patterns of three immunohistochemically identified fiber types within the anterior compartment of the cat tibialis anterior were determined 6 months after denervation and self-reinnervation. After self-reinnervation, mean frequencies of slow (9%) and fast (91%) fibers were similar to those in control (12% and 88%, respectively) muscles. However, a lower proportion of fast-1 (26%) and a higher proportion of fast- 2 (65%) fibers were observed in self-reinnervated than control (32% and 56%) muscles. Quantitation of adjacencies between fibers of similar myosin heavy chain (MHC) phenotype, a measure of type grouping, revealed that the frequencies of two slow or two fast- 1 fibers being adjacent in self- reinnervated muscles were similar to control. In contrast, the frequency of fast-2/fast-2 fiber adjacencies found in self-reinnervated muscles (45%) was significantly higher than in control muscles (37%). In both groups, the frequency of adjacencies between slow, fast-1, or fast-2 fibers was largely attributable to the number of each fiber type present. These data show that the incidence of grouping within each fiber type present was not altered after 6 months of self-reinnervation. Minimal changes in the spatial distribution of fiber types following self-reinnervation in adults suggests a limited degree of conversion of muscle fibers to a MHC phenotype matching the motoneuron characteristics.

Original languageEnglish (US)
Pages (from-to)1320-1327
Number of pages8
JournalMuscle and Nerve
Volume19
Issue number10
DOIs
StatePublished - 1996

Keywords

  • immunohistochemistry
  • myosin heavy chain
  • selective reinnervation
  • self-reinnervation
  • spatial distribution

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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