Limb-sparing surgery for extremity sarcomas after preoperative intraarterial doxorubicin and radiation therapy

James E Goodnight Jr, William L. Bargar, Thomas Voegeli, F. William Blaisdell

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Complete local control of 25 extremity bone and soft tissue sarcomas was obtained by combined preoperative intraarterial doxorubicin and radiation therapy, followed by limb-sparing resection with reconstruction and adjuvant chemotherapy. At a 32 month median follow-up, there are no local tumor recurrences. Functional limbs were salvaged in 21 patients (84 percent). Fifteen patients (60 percent) were continuously disease-free and overall survival was 80 percent. After the extensive combined modality therapy, extremity complications, including delays in wound healing, occurred in 10 patients. Nevertheless, most complications were resolved with salvage of functional limbs. These results support an aggressive multimodality limb-sparing approach to high-grade extremity sarcomas.

Original languageEnglish (US)
Pages (from-to)109-113
Number of pages5
JournalThe American Journal of Surgery
Volume150
Issue number1
DOIs
StatePublished - 1985

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Sarcoma
Doxorubicin
Radiotherapy
Extremities
Combined Modality Therapy
Limb Salvage
Adjuvant Chemotherapy
Wound Healing
Disease-Free Survival
Bone and Bones
Recurrence
Neoplasms

ASJC Scopus subject areas

  • Surgery

Cite this

Limb-sparing surgery for extremity sarcomas after preoperative intraarterial doxorubicin and radiation therapy. / Goodnight Jr, James E; Bargar, William L.; Voegeli, Thomas; Blaisdell, F. William.

In: The American Journal of Surgery, Vol. 150, No. 1, 1985, p. 109-113.

Research output: Contribution to journalArticle

Goodnight Jr, James E ; Bargar, William L. ; Voegeli, Thomas ; Blaisdell, F. William. / Limb-sparing surgery for extremity sarcomas after preoperative intraarterial doxorubicin and radiation therapy. In: The American Journal of Surgery. 1985 ; Vol. 150, No. 1. pp. 109-113.
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