Light regulates expression of a Fos-related protein in rat suprachiasmatic nuclei

Neil Aronin; Stephen M. Sagar; Frank R Sharp; William J. Schwartz

Light regulates expression of a Fos-related protein in rat suprachiasmatic nuclei

Neil Aronin, Stephen M. Sagar, Frank R Sharp, William J. Schwartz

Research output: Contribution to journal › Article › peer-review

Abstract

Mammalian circadian rhythmicity is endogenously generated by a pacemaker in the suprachiasmatic nuclei and precisely entrained to the 24-hr day/night cycle by periodic environmental light cues. We show that light alters the immunoreactive levels of a transcriptional regulatory protein, Fos, in the suprachiasmatic nuclei of albino rats. Photic regulation of Fos immunoreactivity does not occur in other retino-recipient brain areas except for the intergeniculate leaflet, which appears to be involved in mediating some of the complex effects of light on expressed circadian rhythms. Our results point to a promising new functional marker for the cellular effects of light and suggest that the expression of Fos or a related nuclear protein may be part of the mechanism for photic entrainment of the circadian clock to environmental light/dark cycles. (.

Original language	English (US)
Pages (from-to)	5959-5962
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	87
Issue number	15
State	Published - 1990
Externally published	Yes

Keywords

Circadian rhythm
Hypothalamus
Transcription factor

ASJC Scopus subject areas

Genetics
General

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T1 - Light regulates expression of a Fos-related protein in rat suprachiasmatic nuclei

AU - Aronin, Neil

AU - Sagar, Stephen M.

AU - Sharp, Frank R

AU - Schwartz, William J.

PY - 1990

Y1 - 1990

N2 - Mammalian circadian rhythmicity is endogenously generated by a pacemaker in the suprachiasmatic nuclei and precisely entrained to the 24-hr day/night cycle by periodic environmental light cues. We show that light alters the immunoreactive levels of a transcriptional regulatory protein, Fos, in the suprachiasmatic nuclei of albino rats. Photic regulation of Fos immunoreactivity does not occur in other retino-recipient brain areas except for the intergeniculate leaflet, which appears to be involved in mediating some of the complex effects of light on expressed circadian rhythms. Our results point to a promising new functional marker for the cellular effects of light and suggest that the expression of Fos or a related nuclear protein may be part of the mechanism for photic entrainment of the circadian clock to environmental light/dark cycles. (.

AB - Mammalian circadian rhythmicity is endogenously generated by a pacemaker in the suprachiasmatic nuclei and precisely entrained to the 24-hr day/night cycle by periodic environmental light cues. We show that light alters the immunoreactive levels of a transcriptional regulatory protein, Fos, in the suprachiasmatic nuclei of albino rats. Photic regulation of Fos immunoreactivity does not occur in other retino-recipient brain areas except for the intergeniculate leaflet, which appears to be involved in mediating some of the complex effects of light on expressed circadian rhythms. Our results point to a promising new functional marker for the cellular effects of light and suggest that the expression of Fos or a related nuclear protein may be part of the mechanism for photic entrainment of the circadian clock to environmental light/dark cycles. (.

KW - Circadian rhythm

KW - Hypothalamus

KW - Transcription factor

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