Abstract
Mammalian circadian rhythmicity is endogenously generated by a pacemaker in the suprachiasmatic nuclei and precisely entrained to the 24-hr day/night cycle by periodic environmental light cues. We show that light alters the immunoreactive levels of a transcriptional regulatory protein, Fos, in the suprachiasmatic nuclei of albino rats. Photic regulation of Fos immunoreactivity does not occur in other retino-recipient brain areas except for the intergeniculate leaflet, which appears to be involved in mediating some of the complex effects of light on expressed circadian rhythms. Our results point to a promising new functional marker for the cellular effects of light and suggest that the expression of Fos or a related nuclear protein may be part of the mechanism for photic entrainment of the circadian clock to environmental light/dark cycles. (.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5959-5962 |
| Number of pages | 4 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 87 |
| Issue number | 15 |
| State | Published - 1990 |
| Externally published | Yes |
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Keywords
- Circadian rhythm
- Hypothalamus
- Transcription factor
ASJC Scopus subject areas
- Genetics
- General
Cite this
Light regulates expression of a Fos-related protein in rat suprachiasmatic nuclei. / Aronin, Neil; Sagar, Stephen M.; Sharp, Frank R; Schwartz, William J.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, No. 15, 1990, p. 5959-5962.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Light regulates expression of a Fos-related protein in rat suprachiasmatic nuclei
AU - Aronin, Neil
AU - Sagar, Stephen M.
AU - Sharp, Frank R
AU - Schwartz, William J.
PY - 1990
Y1 - 1990
N2 - Mammalian circadian rhythmicity is endogenously generated by a pacemaker in the suprachiasmatic nuclei and precisely entrained to the 24-hr day/night cycle by periodic environmental light cues. We show that light alters the immunoreactive levels of a transcriptional regulatory protein, Fos, in the suprachiasmatic nuclei of albino rats. Photic regulation of Fos immunoreactivity does not occur in other retino-recipient brain areas except for the intergeniculate leaflet, which appears to be involved in mediating some of the complex effects of light on expressed circadian rhythms. Our results point to a promising new functional marker for the cellular effects of light and suggest that the expression of Fos or a related nuclear protein may be part of the mechanism for photic entrainment of the circadian clock to environmental light/dark cycles. (.
AB - Mammalian circadian rhythmicity is endogenously generated by a pacemaker in the suprachiasmatic nuclei and precisely entrained to the 24-hr day/night cycle by periodic environmental light cues. We show that light alters the immunoreactive levels of a transcriptional regulatory protein, Fos, in the suprachiasmatic nuclei of albino rats. Photic regulation of Fos immunoreactivity does not occur in other retino-recipient brain areas except for the intergeniculate leaflet, which appears to be involved in mediating some of the complex effects of light on expressed circadian rhythms. Our results point to a promising new functional marker for the cellular effects of light and suggest that the expression of Fos or a related nuclear protein may be part of the mechanism for photic entrainment of the circadian clock to environmental light/dark cycles. (.
KW - Circadian rhythm
KW - Hypothalamus
KW - Transcription factor
UR - http://www.scopus.com/inward/record.url?scp=0025311122&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025311122&partnerID=8YFLogxK
M3 - Article
C2 - 2116012
AN - SCOPUS:0025311122
VL - 87
SP - 5959
EP - 5962
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 15
ER -