Light induces a Fos0like nuclear antigen in retinal neurons

Stephen M. Sagar, Frank R Sharp

Research output: Contribution to journalArticle

133 Scopus citations

Abstract

Fos, the product of the proto-oncogene c-fos, is a nuclear phosphoprotein thought to participate in transcriptional regulation of target genes. To explore the synaptic induction of Fos and related proteins in vivo, Fos immunohistochemistry was performed in the rabbit retina. Dark-adapted retinas had virtually no Fos immunostaining. Retinas of dark-adapted rabbits that were exposed to 3 Hz diffuse flashing white light for 1 h and sacrificed 2 h later displayed nuclear Fos immunostaining in a minority of neurons. These included presumptive amacrine cells of the inner nuclear layer and either displaced amacrine cells or ganglion cells of the ganglion cell layer. Therefore, Fos or a related antigen is expressed in a subset of retinal neurons in response to light and is presumably involved in regulating gene expression of these cells to respond to alterations in synaptic activity.

Original languageEnglish (US)
Pages (from-to)17-21
Number of pages5
JournalMolecular Brain Research
Volume7
Issue number1
DOIs
StatePublished - 1990
Externally publishedYes

Keywords

  • Amacrine cell
  • C-fos
  • Proto-oncogene

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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