Light, including ultraviolet

Emanual Michael Maverakis, Yoshinori Miyamura, Michael P. Bowen, Genevieve Correa, Yoko Ono, Heidi Goodarzi

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

Ultraviolet (UV) light is intricately linked to the functional status of the cutaneous immune system. In susceptible individuals, UV radiation can ignite pathogenic inflammatory pathways leading to allergy or autoimmunity. In others, this same UV radiation can be used as a phototherapy to suppress pathogenic cutaneous immune responses. These vastly different properties are a direct result of UV light's ability to ionize molecules in the skin and thereby chemically alter them. Sometimes these UV-induced chemical reactions are essential, the formation of pre-vitamin D3 from 7-dehydrocholesterol, for example. In other instances they can be potentially detrimental. UV radiation can ionize a cell's DNA causing adjacent pyrimidine bases to chemically bond to each other. To prevent malignant transformation, a cell may respond to this UV-induced DNA damage by undergoing apoptosis. Although this pathway prevents skin cancer it also has the potential of inducing or exacerbating autoreactive immune responses by exposing the cell's nuclear antigens. Ultaviolet-induced chemical reactions can activate the immune system by a variety of other mechanisms as well. In response to UV irradiation keratinocytes secrete cytokines and chemokines, which activate and recruit leukocytes to the skin. In some individuals UV-induced chemical reactions can synthesize novel antigens resulting in a photoallergy. Alternatively, photosensitizing molecules can damage cells by initiating sunburn-like phototoxic reactions. Herein we review all types of UV-induced skin reactions, especially those involving the immune system.

Original languageEnglish (US)
JournalJournal of Autoimmunity
Volume34
Issue number3
DOIs
StatePublished - May 2010

Fingerprint

Ultraviolet Rays
Skin
Immune System
Radiation
Photoallergic Dermatitis
Sunburn
Nuclear Antigens
Phototherapy
Cholecalciferol
Skin Neoplasms
Autoimmunity
Keratinocytes
Chemokines
DNA Damage
Hypersensitivity
Leukocytes
Apoptosis
Cytokines
Antigens
DNA

Keywords

  • Autoimmunity
  • Photoallergic reaction
  • Phototherapy
  • Phototoxic reaction
  • Skin
  • Ultraviolet radiation

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Maverakis, E. M., Miyamura, Y., Bowen, M. P., Correa, G., Ono, Y., & Goodarzi, H. (2010). Light, including ultraviolet. Journal of Autoimmunity, 34(3). https://doi.org/10.1016/j.jaut.2009.11.011

Light, including ultraviolet. / Maverakis, Emanual Michael; Miyamura, Yoshinori; Bowen, Michael P.; Correa, Genevieve; Ono, Yoko; Goodarzi, Heidi.

In: Journal of Autoimmunity, Vol. 34, No. 3, 05.2010.

Research output: Contribution to journalArticle

Maverakis, EM, Miyamura, Y, Bowen, MP, Correa, G, Ono, Y & Goodarzi, H 2010, 'Light, including ultraviolet', Journal of Autoimmunity, vol. 34, no. 3. https://doi.org/10.1016/j.jaut.2009.11.011
Maverakis EM, Miyamura Y, Bowen MP, Correa G, Ono Y, Goodarzi H. Light, including ultraviolet. Journal of Autoimmunity. 2010 May;34(3). https://doi.org/10.1016/j.jaut.2009.11.011
Maverakis, Emanual Michael ; Miyamura, Yoshinori ; Bowen, Michael P. ; Correa, Genevieve ; Ono, Yoko ; Goodarzi, Heidi. / Light, including ultraviolet. In: Journal of Autoimmunity. 2010 ; Vol. 34, No. 3.
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