Light-driven translocation of signaling proteins in vertebrate photoreceptors

Peter D. Calvert, Katherine J. Strissel, William E. Schiesser, Edward N Pugh Jr, Vadim Y. Arshavsky

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

The dynamic localization of proteins within cells is often determined by environmental stimuli. In retinal photoreceptors, light exposure results in the massive translocation of three key signal transduction proteins, transducin, arrestin and recoverin, into and out of the outer segment compartment where phototransduction takes place. This phenomenon has rapidly taken the center stage of photoreceptor cell biology, thanks to the introduction of new quantitative and transgenic approaches. Here, we discuss evidence that intracellular protein translocation contributes to adaptation of photoreceptors to diurnal changes in ambient light intensity and summarize the current debate on whether it is driven by diffusion or molecular motors.

Original languageEnglish (US)
Pages (from-to)560-568
Number of pages9
JournalTrends in Cell Biology
Volume16
Issue number11
DOIs
StatePublished - Nov 2006
Externally publishedYes

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Vertebrate Photoreceptor Cells
Protein Transport
Recoverin
Transducin
Light Signal Transduction
Arrestin
Light
Photoreceptor Cells
Cell Biology
Signal Transduction
Proteins

ASJC Scopus subject areas

  • Cell Biology

Cite this

Light-driven translocation of signaling proteins in vertebrate photoreceptors. / Calvert, Peter D.; Strissel, Katherine J.; Schiesser, William E.; Pugh Jr, Edward N; Arshavsky, Vadim Y.

In: Trends in Cell Biology, Vol. 16, No. 11, 11.2006, p. 560-568.

Research output: Contribution to journalArticle

Calvert, Peter D. ; Strissel, Katherine J. ; Schiesser, William E. ; Pugh Jr, Edward N ; Arshavsky, Vadim Y. / Light-driven translocation of signaling proteins in vertebrate photoreceptors. In: Trends in Cell Biology. 2006 ; Vol. 16, No. 11. pp. 560-568.
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