Lifetime fluorescence apparatus for clinical investigations of tissues

Laura Marcu, Qiyin Fang, Thanassis Papaioannou, Javier A. Jo, Russel Vaitha, Kumar Shastry

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We report on the design, development, and performance of a versatile and mobile fiber-optic based time-resolved fluorescence apparatus for in-vivo spectroscopy of biological tissues. The apparatus is of modular design which allows for facile interfacing with different pulsed light sources and fiber-optic probes. Main features of the apparatus include: 1) fast acquisition of fluorescence decays with high temporal resolution (0.3 ns) for a broad range of emission wavelengths (300 to 850 nm) and lifetimes (0.3 ns to ms), 2) near real time analysis of fluorescence decays via a Laguerre deconvolution technique, and 3) compatibility with the clinical environment (endoscopic procedures or other intraoperative uses). The apparatus is currently employed for in-vivo studies of diseased tissues (cardiovascular and oncological applications).

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsG.A. Wagnieres
Pages40-46
Number of pages7
Volume5141
StatePublished - 2003
Externally publishedYes
EventDiagnostic Optical Spectroscopy in Biomedicine II - Munich, Germany
Duration: Jun 24 2003Jun 25 2003

Other

OtherDiagnostic Optical Spectroscopy in Biomedicine II
CountryGermany
CityMunich
Period6/24/036/25/03

Fingerprint

Fluorescence
Tissue
life (durability)
fluorescence
Fiber optics
fiber optics
Deconvolution
Light sources
decay
temporal resolution
Spectroscopy
compatibility
Wavelength
acquisition
light sources
probes
high resolution
wavelengths
spectroscopy

Keywords

  • Arterial diseases
  • Fiberoptic probes
  • Intraoperative diagnostics
  • Time-resolved fluorescence spectroscopy

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Marcu, L., Fang, Q., Papaioannou, T., Jo, J. A., Vaitha, R., & Shastry, K. (2003). Lifetime fluorescence apparatus for clinical investigations of tissues. In G. A. Wagnieres (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 5141, pp. 40-46)

Lifetime fluorescence apparatus for clinical investigations of tissues. / Marcu, Laura; Fang, Qiyin; Papaioannou, Thanassis; Jo, Javier A.; Vaitha, Russel; Shastry, Kumar.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / G.A. Wagnieres. Vol. 5141 2003. p. 40-46.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Marcu, L, Fang, Q, Papaioannou, T, Jo, JA, Vaitha, R & Shastry, K 2003, Lifetime fluorescence apparatus for clinical investigations of tissues. in GA Wagnieres (ed.), Proceedings of SPIE - The International Society for Optical Engineering. vol. 5141, pp. 40-46, Diagnostic Optical Spectroscopy in Biomedicine II, Munich, Germany, 6/24/03.
Marcu L, Fang Q, Papaioannou T, Jo JA, Vaitha R, Shastry K. Lifetime fluorescence apparatus for clinical investigations of tissues. In Wagnieres GA, editor, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 5141. 2003. p. 40-46
Marcu, Laura ; Fang, Qiyin ; Papaioannou, Thanassis ; Jo, Javier A. ; Vaitha, Russel ; Shastry, Kumar. / Lifetime fluorescence apparatus for clinical investigations of tissues. Proceedings of SPIE - The International Society for Optical Engineering. editor / G.A. Wagnieres. Vol. 5141 2003. pp. 40-46
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