Lifelong feeding of a high aluminum diet to mice

Mari S. Golub, Stacey L. Germann, Bin Han, Carl L Keen

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

In three experiments, high aluminum diets (1000 μg Al/g diet) were fed to mice throughout their life span to determine whether neurodegenerative changes were seen with aging. Brain Al concentrations were slightly lower in Al-treated mice than controls. Generally, no increased mortality or gross evidence of neurodegeneration was seen in Al-treated mice. Eighteen and 24 month old Swiss Webster mice fed the high aluminum diet differed from controls on some neurobehavioral tests, but differences were no greater than previously seen with shorter term exposure in younger mice. Both brain Al concentration and susceptibility to oxidative damage, as measured with TBARS, were lower in the Al-treated aged mice than in controls. In addition, Al-treated aged Swiss Webster and C57BL/6J mice showed somewhat enhanced performance in the Morris water maze. Finally, Al treatment did not exacerbate the effect of MPTP treatment on a grip strength measure in either 66 or 235 day old male mice. Swiss Webster and C57BL/6J mice do not appear to provide useful models for studying Al-induced neurodegenerative changes in aging. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)107-117
Number of pages11
JournalToxicology
Volume150
Issue number1-3
DOIs
StatePublished - Sep 7 2000

Keywords

  • Aging mice
  • Aluminum
  • Brain behavior
  • Iron manganese
  • Lipid peroxidation
  • MPTP

ASJC Scopus subject areas

  • Toxicology

Fingerprint Dive into the research topics of 'Lifelong feeding of a high aluminum diet to mice'. Together they form a unique fingerprint.

  • Cite this

    Golub, M. S., Germann, S. L., Han, B., & Keen, C. L. (2000). Lifelong feeding of a high aluminum diet to mice. Toxicology, 150(1-3), 107-117. https://doi.org/10.1016/S0300-483X(00)00251-1