Life-threatening extrarenal lupus in children despite improvement in serologic findings

Lavjay Butani, Sudesh P Makker

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Systemic lupus erythematosus (SLE) is an autoimmune disorder with the potential for multiorgan involvement. Serologic tests are helpful in establishing the diagnosis of SLE and predicting disease flares. However, there are few data on the relationship between the onset of new organ involvement and lupus serologies, especially in children. This report details our experience in managing two children with lupus nephritis. Both developed life-threatening extrarenal complications (cerebritis and carditis) soon after receiving high-dose immunosuppressive therapy and despite normalizing serologies. This lack of concordance between serologies and the development of carditis and cerebritis needs to be recognized so that health care professionals treating children with SLE can promptly intensify immunosuppressive medications and avoid life-threatening delays from seeking alternative explanations for symptomatology.

Original languageEnglish (US)
Pages (from-to)92-95
Number of pages4
JournalRheumatology International
Issue number2
StatePublished - Mar 2003


  • Cardiomyopathy
  • Central nervous system lupus erythematosus
  • Lupus erythematosus
  • Mitral regurgitation
  • Serology

ASJC Scopus subject areas

  • Rheumatology


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