Abstract
Simian virus 40 (SV40) is a non-enveloped DNA virus. It is known to have been accidentally introduced to a large segment of the human population during the mid-20th century through tainted polio vaccines produced in the kidney cells of African green monkeys and rhesusu monkeys. Studies have indicated that when the virus invades certain mammalian cells, its reproduction is often hindered, but the virus may produce T-antigen and incite oncogenic transformation in the host. SV40 has been shown to incite tumor growth in rodents and may be linked to the development of mesothelioma and certain other kinds of cancer in humans. Therefore, SV40 has been well analyzed as a tumor model. Recently, the host cell receptors for SV40 have been identified and it has been shown to pass from surface caveolae to the endoplasmic reticulum in apparently novel infectious entry pathway. Virus-like particles (VLPs) of polyomavirus has been shown to enter into cells in the same way as polyomavirus virion, suggesting the possibility that VLPs can be used as the carrier of drug delivery system through the use of the polyomavirus infectious pathway.
| Original language | English (US) |
|---|---|
| Title of host publication | Structure-Based Study of Viral Replication: (With CD-Rom) |
| Publisher | World Scientific Publishing Co. |
| Pages | 609-629 |
| Number of pages | 21 |
| ISBN (Electronic) | 9789812790859 |
| ISBN (Print) | 9812704051, 9789812704054 |
| DOIs | |
| State | Published - Jan 1 2008 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Engineering(all)
- Immunology and Microbiology(all)
Cite this
Life cycles of polyomaviridae-DNA tumor virus. / Kawano, Masaaki; Handa, Hiroshi; Holland Cheng, R.
Structure-Based Study of Viral Replication: (With CD-Rom). World Scientific Publishing Co., 2008. p. 609-629.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Life cycles of polyomaviridae-DNA tumor virus
AU - Kawano, Masaaki
AU - Handa, Hiroshi
AU - Holland Cheng, R.
PY - 2008/1/1
Y1 - 2008/1/1
N2 - Simian virus 40 (SV40) is a non-enveloped DNA virus. It is known to have been accidentally introduced to a large segment of the human population during the mid-20th century through tainted polio vaccines produced in the kidney cells of African green monkeys and rhesusu monkeys. Studies have indicated that when the virus invades certain mammalian cells, its reproduction is often hindered, but the virus may produce T-antigen and incite oncogenic transformation in the host. SV40 has been shown to incite tumor growth in rodents and may be linked to the development of mesothelioma and certain other kinds of cancer in humans. Therefore, SV40 has been well analyzed as a tumor model. Recently, the host cell receptors for SV40 have been identified and it has been shown to pass from surface caveolae to the endoplasmic reticulum in apparently novel infectious entry pathway. Virus-like particles (VLPs) of polyomavirus has been shown to enter into cells in the same way as polyomavirus virion, suggesting the possibility that VLPs can be used as the carrier of drug delivery system through the use of the polyomavirus infectious pathway.
AB - Simian virus 40 (SV40) is a non-enveloped DNA virus. It is known to have been accidentally introduced to a large segment of the human population during the mid-20th century through tainted polio vaccines produced in the kidney cells of African green monkeys and rhesusu monkeys. Studies have indicated that when the virus invades certain mammalian cells, its reproduction is often hindered, but the virus may produce T-antigen and incite oncogenic transformation in the host. SV40 has been shown to incite tumor growth in rodents and may be linked to the development of mesothelioma and certain other kinds of cancer in humans. Therefore, SV40 has been well analyzed as a tumor model. Recently, the host cell receptors for SV40 have been identified and it has been shown to pass from surface caveolae to the endoplasmic reticulum in apparently novel infectious entry pathway. Virus-like particles (VLPs) of polyomavirus has been shown to enter into cells in the same way as polyomavirus virion, suggesting the possibility that VLPs can be used as the carrier of drug delivery system through the use of the polyomavirus infectious pathway.
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UR - http://www.scopus.com/inward/citedby.url?scp=84969185795&partnerID=8YFLogxK
U2 - 10.1142/9789812790859_0024
DO - 10.1142/9789812790859_0024
M3 - Chapter
AN - SCOPUS:84969185795
SN - 9812704051
SN - 9789812704054
SP - 609
EP - 629
BT - Structure-Based Study of Viral Replication: (With CD-Rom)
PB - World Scientific Publishing Co.
ER -