Life cycles of polyomaviridae-DNA tumor virus

Masaaki Kawano, Hiroshi Handa, R. Holland Cheng

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Simian virus 40 (SV40) is a non-enveloped DNA virus. It is known to have been accidentally introduced to a large segment of the human population during the mid-20th century through tainted polio vaccines produced in the kidney cells of African green monkeys and rhesusu monkeys. Studies have indicated that when the virus invades certain mammalian cells, its reproduction is often hindered, but the virus may produce T-antigen and incite oncogenic transformation in the host. SV40 has been shown to incite tumor growth in rodents and may be linked to the development of mesothelioma and certain other kinds of cancer in humans. Therefore, SV40 has been well analyzed as a tumor model. Recently, the host cell receptors for SV40 have been identified and it has been shown to pass from surface caveolae to the endoplasmic reticulum in apparently novel infectious entry pathway. Virus-like particles (VLPs) of polyomavirus has been shown to enter into cells in the same way as polyomavirus virion, suggesting the possibility that VLPs can be used as the carrier of drug delivery system through the use of the polyomavirus infectious pathway.

Original languageEnglish (US)
Title of host publicationStructure-Based Study of Viral Replication: (With CD-Rom)
PublisherWorld Scientific Publishing Co.
Pages609-629
Number of pages21
ISBN (Electronic)9789812790859
ISBN (Print)9812704051, 9789812704054
DOIs
StatePublished - Jan 1 2008

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Immunology and Microbiology(all)

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  • Cite this

    Kawano, M., Handa, H., & Holland Cheng, R. (2008). Life cycles of polyomaviridae-DNA tumor virus. In Structure-Based Study of Viral Replication: (With CD-Rom) (pp. 609-629). World Scientific Publishing Co.. https://doi.org/10.1142/9789812790859_0024